Antibacterial polyurethanes, modifed with cinnamaldehyde, as potential materials for fabrication of wound dressings - Publication - MOST Wiedzy

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Antibacterial polyurethanes, modifed with cinnamaldehyde, as potential materials for fabrication of wound dressings

Abstract

The epidermis is a skin layer, which protects an organism from the different factors of external environment. Therefore, the fast and effective regeneration of epidermis is important. Potential materials used for epidermis regeneration may be polyurethane scaffolds in form of the thin permeable layers. One and main disadvantage of such polyurethane scaffolds are their lack of antibacterial and antifungal properties. The great proposition to improve antiseptic properties of polyurethane epidermis scaffolds is to modify them with the use of substances, which reveal antiseptic, antimicrobial, and/or antifungal properties like cinnamaldehyde (CA). The great advantage speaking in favor of this compound is the fact that it has been approved and concerned as generally safe by the Food and Drug Administration in the USA. In this paper was described the fabrication of antibacterial microporous polyurethane scaffolds (MPTLs) in a form of a thin layers by using solvent-casting/particulateleaching technique combined with thermally induced phase separation. Obtained MPTLs were modified with CA at different concentrations (0.5–5%): to establish the most suitable antibacterial effect of the CA introduced into the MPTLs matrix. Obtained unmodified and CA-modified MPTLs were characterized by mechanical and physicochemical properties as well as by identification of their antibacterial performance. The performed studies revealed that the most relevant antimicrobial effect of CA-modified MPTLs was observed when the CA concentration was 3.5%.

Citations

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Details

Category:
Magazine publication
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
POLYMER BULLETIN pages 1 - 18,
ISSN: 0170-0839
Language:
English
Publication year:
2018
Bibliographic description:
Kucińska-Lipka J., Gubańska I., Lewandowska A., Terebieniec A., Przybytek A., Cieśliński H.: Antibacterial polyurethanes, modifed with cinnamaldehyde, as potential materials for fabrication of wound dressings// POLYMER BULLETIN. -, (2018), s.1-18
DOI:
Digital Object Identifier (open in new tab) 10.1007/s00289-018-2512-x
Verification:
Gdańsk University of Technology

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