Antibacterial polyurethanes, modifed with cinnamaldehyde, as potential materials for fabrication of wound dressings - Publication - MOST Wiedzy


Antibacterial polyurethanes, modifed with cinnamaldehyde, as potential materials for fabrication of wound dressings


The epidermis is a skin layer, which protects an organism from the different factors of external environment. Therefore, the fast and effective regeneration of epidermis is important. Potential materials used for epidermis regeneration may be polyurethane scaffolds in form of the thin permeable layers. One and main disadvantage of such polyurethane scaffolds are their lack of antibacterial and antifungal properties. The great proposition to improve antiseptic properties of polyurethane epidermis scaffolds is to modify them with the use of substances, which reveal antiseptic, antimicrobial, and/or antifungal properties like cinnamaldehyde (CA). The great advantage speaking in favor of this compound is the fact that it has been approved and concerned as generally safe by the Food and Drug Administration in the USA. In this paper was described the fabrication of antibacterial microporous polyurethane scaffolds (MPTLs) in a form of a thin layers by using solvent-casting/particulateleaching technique combined with thermally induced phase separation. Obtained MPTLs were modified with CA at different concentrations (0.5–5%): to establish the most suitable antibacterial effect of the CA introduced into the MPTLs matrix. Obtained unmodified and CA-modified MPTLs were characterized by mechanical and physicochemical properties as well as by identification of their antibacterial performance. The performed studies revealed that the most relevant antimicrobial effect of CA-modified MPTLs was observed when the CA concentration was 3.5%.


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artykuł w czasopiśmie wyróżnionym w JCR
Published in:
POLYMER BULLETIN no. 76, pages 2725 - 2742,
ISSN: 0170-0839
Publication year:
Bibliographic description:
Kucińska-Lipka J., Gubańska I., Lewandowska A., Terebieniec A., Haryńska A., Cieśliński H.: Antibacterial polyurethanes, modifed with cinnamaldehyde, as potential materials for fabrication of wound dressings// POLYMER BULLETIN. -Vol. 76, (2018), s.2725-2742
Digital Object Identifier (open in new tab) 10.1007/s00289-018-2512-x
Bibliography: test
  1. Esteban-vives R, Young MT, Ziembicki J et al (2015) ScienceDirect Effects of wound dressings on cultured primary keratinocytes. Burns. https :// .2015.06.016 open in new tab
  2. Anjum S, Arora A, Alam MS, Gupta B (2016) Development of antimicrobial and scar preven- tive chitosan hydrogel wound dressings. Int J Pharm 508:92-101. https :// rm.2016.05.013 open in new tab
  3. Vowden K (2017) Wound dressings: principles and practice. Surgery 35:489-494. https ://doi. org/10.1016/j.mpsur .2017.06.005 open in new tab
  4. Koosehgol S, Ebrahimian-hosseinabadi M, Alizadeh M, Zamanian A (2017) Preparation and char- acterization of in situ chitosan/polyethylene glycol fumarate/thymol hydrogel as an effective wound dressing. Mater Sci Eng, C 79:66-75. https :// open in new tab
  5. Yari A, Yeganeh H, Bakhshi H (2012) Synthesis and evaluation of novel absorptive and antibacte- rial polyurethane membranes as wound dressing. J Mater Sci Mater Med. https :// s1085 6-012-4683-6 open in new tab
  6. Bergamo R, Buzatto C, Alberto J, Maria  (2017) Electrospun multilayer chitosan scaffolds as potential wound dressings for skin lesions. Eur Polym J 88:161-170. https :// lymj.2017.01.021 open in new tab
  7. Fan L, Yang H, Yang J et al (2016) Preparation and characterization of chitosan/gelatin/PVA hydrogel for wound dressings. Carbohydr Polym 146:427-434. https :// ol.2016.03.002 open in new tab
  8. Agarwal T, Narayan R, Maji S, Behera S (2016) Gelatin/carboxymethyl chitosan based scaf- folds for dermal tissue engineering applications. Int J Biol Macromol 93:1499-1506. https ://doi. org/10.1016/j.ijbio mac.2016.04.028 open in new tab
  9. Tavakoli J, Tang Y (2017) Honey/PVA hybrid wound dressings with controlled release of antibiot- ics: structural, physico-mechanical and in vitro biomedical studies. Mater Sci Eng, C 77:318-325. https :// open in new tab
  10. Ganesan P (2017) Natural and bio polymer curative films for wound dressing medical applications. Biochem Pharmacol 18:33-40. https :// open in new tab
  11. Xie H, Chen X, Shen X et al (2017) Preparation of chitosan-collagen-alginate composite dressing and its promoting effects on wound healing. Int J Biol Macromol. https :// mac.2017.08.142 open in new tab
  12. Rieger KA, Schiffman JD (2014) Electrospinning an essential oil: cinnamaldehyde enhances the antimicrobial efficacy of chitosan/poly(ethylene oxide) nanofibers. Carbohydr Polym 113:561-568. https :// ol.2014.06.075 open in new tab
  13. Kamoun EA, Kenawy ES, Chen X (2017) A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings. J Adv Res 8:217-233. https ://doi. org/10.1016/j.jare.2017.01.005 open in new tab
  14. Witold Brostow HEH, Lobland HEH (2017) Materials: introduction and applications. Wiley, Hoboken open in new tab
  15. Chua AWC, Ma DR, Song IC et al (2008) In vitro evaluation of fibrin mat and Tegaderm™ wound dressing for the delivery of keratinocytes-implications of their use to treat burns. Burns 34:175- 180. https :// .2007.07.009 open in new tab
  16. Czemplik M, Kulma A, Szopa J (2013) The local treatment and available dressings designed for chronic wounds. J Am Acad Dermatol. https :// open in new tab
  17. Lin Y, Lee G, Chou C et al (2015) Stimulation of wound healing by PU/hydrogel composites con- taining fi broblast growth factor-2. J Mater Chem B Mater Biol Med 3:1931-1941. https ://doi. org/10.1039/C4TB0 1638F open in new tab
  18. Oh S, Kim W, Kim S et al (2011) The preparation of polyurethane foam combined with pH-sen- sitive alginate/bentonite hydrogel for wound dressings. Fibers Polymers 12:159-165. https ://doi. org/10.1007/s1222 1-011-0159-4 open in new tab
  19. Manikandan A, Prasath M, Kumar S (2017) Formation of functional nano fi brous electrospun polyurethane and murivenna oil with improved haemocompatibility for wound healing. Polym Test 61:106-113. https :// ertes ting.2017.05.008 open in new tab
  20. Patel DK, Rana D, Aswal VK et al (2015) Influence of graphene on self-assembly of polyu- rethane and evaluation of its biomedical properties. Polymer (Guildf) 65:183-192. https ://doi. org/10.1016/j.polym er.2015.03.076 open in new tab
  21. Tsai M, Hung K, Hung S, Hsu S (2015) Evaluation of biodegradable elastic scaffolds made of anionic polyurethane for cartilage tissue engineering. Colloids Surf B Biointerfaces 125:34-44. https :// rfb.2014.11.003 open in new tab
  22. Mi H, Salick MR, Jing X et al (2013) Characterization of thermoplastic polyurethane/polylac- tic acid (TPU/PLA) tissue engineering scaffolds fabricated by microcellular injection molding. Mater Sci Eng, C 33:4767-4776. https :// open in new tab
  23. Janik H, Marzec M (2015) A review: fabrication of porous polyurethane scaffolds. Mater Sci Eng, C 48:586-591. https :// open in new tab
  24. Mi H, Jing X, Salick MR et al (2016) Carbon nanotube (CNT) and nano fi brillated cellulose (NFC) reinforcement effect on thermoplastic polyurethane (TPU) scaffolds fabricated via phase separation using dimethyl sulfoxide (DMSO) as solvent. J Mech Behav Biomed Mater 62:417- 427. https :// .2016.05.026 open in new tab
  25. Gabriel LP, Amélia A, Macedo M et al (2017) Electrospun polyurethane membranes for tis- sue engineering applications. Mater Sci Eng, C 72:113-117. https :// msec.2016.11.057 open in new tab
  26. Hung K, Tseng C, Dai L, Hsu S (2016) Biomaterials water-based polyurethane 3D printed scaf- folds with controlled release function for customized cartilage tissue engineering. Biomaterials 83:156-168. https :// teria ls.2016.01.019 open in new tab
  27. Benítez JM, Montáns FJ (2017) The mechanical behavior of skin: structures and models for the finite element analysis. Comput Struct 190:75-107. https :// truc.2017.05.003 open in new tab
  28. Kucińska-Lipka J, Gubanska I, Skwarska A (2017) Microporous polyurethane thin layer as a promising scaffold for tissue engineering. Polymers (Basel) 9:277. https :// 90702 77 open in new tab
  29. Shen S, Zhang T, Yuan Y et al (2015) Effects of cinnamaldehyde on Escherichia coli and Staphylococcus aureus membrane. Food Control 47:196-202. https :// ont.2014.07.003 open in new tab
  30. Al-Bayati FA, Muthanna MJ (2009) Isolation, identification, and purification of cinnamaldehyde from cinnamomum zeylanicum bark oil. An antibacterial study. Pharm Biol. 47(1): 61-66. https :// 20080 24306 07 open in new tab
  31. Shreaz S, Wani WA, Behbehani JM et al (2016) Fitoterapia Cinnamaldehyde and its deriva- tives, a novel class of antifungal agents. Fitoterapia 112:116-131. https :// e.2016.05.016 open in new tab
  32. Kwon YS, Lee SH, Hwang YC et al (2017) Behaviour of human dental pulp cells cultured in a collagen hydrogel scaffold cross-linked with cinnamaldehyde. Int Endod J. https ://doi. org/10.1111/iej.12592 open in new tab
  33. Nostro A, Scaffaro R, Arrigo MD, Botta L, Filocamo A, Marino A (2012) Study on carvacrol and cinnamaldehyde polymeric films: mechanical properties, release kinetics and antibacterial and antibiofilm activities. Appl Microb Cell Physiol. https :// 3-012-4091-3 open in new tab
  34. Song Y-R, Choi M-S, Choi G-W, Park I-K, Oh C-S (2016) Antibacterial activity of cinna- maldehyde and estragole extracted from plant essential oils against pseudomonas syringae pv. actinidiae causing bacterial canker disease in kiwifruit. Plant Pathol J 32(4):363-370. https ://doi. org/10.5423/PPJ.NT.01.2016.0006 open in new tab
  35. Bauchan G, Lo YM (2014) Antibacterial activity of cinnamaldehyde and sporan against Escheri- chia coli O157:H7 and Salmonella. J Food Process Preserv 38:749-757. https :// jfpp.12026 open in new tab
  36. Sanla-Ead N, Jangchud A, Chonhenchob V, Suppakul P (2012) Antimicrobial activity of cin- namaldehyde and eugenol and their activity after incorporation into cellulose-based packaging films. Packag Technol Sci 25:7-17. https :// open in new tab
  37. Nazzaro F, Fratianni F, De Martino L, Coppola R, De Feo V (2013) Effect of essential oils on pathogenic bacteria. Pharmaceuticals 6:1451-1474. https :// 1451 open in new tab
  38. Zhang Hongmei, Zhou Wenyuan, Zhang Wenyan, Yang Anlin, Liu Yanlan, Jiang Yan, Shao- song Huang JS (2014) Inhibitory effects of citral, cinnamaldehyde, and tea polyphenols on mixed biofilm formation by foodborne Staphylococcus aureus and Salmonella enteritidis. J Food Prot 77:927-933. https :// open in new tab
  39. Jia P, Xue YJ, Duan XJ, Shao SH (2011) Effect of cinnamaldehyde on biofilm formation and sarA expression by methicillin-resistant Staphylococcus aureus. Lett Appl Microbiol. https ://doi. org/10.1111/j.1472-765X.2011.03122 .x open in new tab
  40. Dewi AH, Ana ID, Jansen J (2016) Calcium carbonate hydrogel construct with cynnamaldehyde incorporated to control inflammation during surgical procedure. J Biomed Mater Res, Part A 104:768-774. https :// open in new tab
  41. Nascimento GGF, Locatelli J, Freitas PC, Silva GL (2000) Antibacterial activity of plant extracts and phytochemicals on antibiotic-resistant bacteria. Braz J Microbiol 31:247-256. https ://doi. org/10.1590/S1517 -83822 00000 04000 03 open in new tab
  42. Brostow W, Brumbley S, Gahutishvili M, Hnatchuk N (2016) Arsenic antibacterial polymer com- posites based on poly(vinyl chloride). Macromol Symp 365:258-262. https :// masy.20165 0002 open in new tab
  43. Barbakadze K, Brostow W, Datashvili T et al (2018) Antibiocorrosive epoxy-based coatings with low friction and high scratch resistance. Wear 394-395:228-235. https :// wear.2017.08.006 open in new tab
  44. Kucinska-Lipka J, Gubanska I, Strankowski M et al (2017) Synthesis and characterization of cycloaliphatic hydrophilic polyurethanes, modified with L-ascorbic acid, as materials for soft tis- sue regeneration. Mater Sci Eng, C 75:671-681. https :// open in new tab
  45. Kucińska-Lipka J, Gubanska I, Korchynskyi O et al (2017) The influence of calcium glycer- ophosphate (GPCa) modifier on physicochemical, mechanical and biological performance of pol- yurethanes applicable as biomaterials for bone tissue scaffolds fabrication. Polymers 9(8):329. https :// 90803 29 open in new tab
  46. Špirková Milena, Poręba Rafał, Pavličević Jelena, Kobera Libor, Josef Baldrian MP (2012) Ali- phatic polycarbonate-based polyurethane elastomers and nanocomposites. I. The influence of hard-segment content and macrodiol-constitution on bottom-up self-assembly. J Appl Polym Sci 126:1016-1030
  47. Yilgor I, Yilgor E, Guler IG et al (2006) FTIR investigation of the influence of diisocyanate symmetry on the morphology development in model segmented polyurethanes. Polymer (Guildf) 47:4105-4114. https :// er.2006.02.027 open in new tab
  48. Tian Y, Zhu Y, Bashari M et al (2013) Identification and releasing characteristics of high-amyl- ose corn starch-cinnamaldehyde inclusion complex prepared using ultrasound treatment. Carbo- hydr Polym 91:586-589. https :// ol.2012.09.008 open in new tab
  49. Manukumar HM, Umesha S (2017) Photocrosslinker technology: an antimicrobial efficacy of cinnamaldehyde cross-linked low-density polyethylene (Cin-C-LDPE) as a novel food wrapper. Food Res Int 102:144-155. https :// es.2017.09.095 open in new tab
  50. Yang Z, Chai K, Ji H (2011) Selective inclusion and separation of cinnamaldehyde and ben- zaldehyde by insoluble β-cyclodextrin polymer. Sep Purif Technol 80:209-216. https ://doi. org/10.1016/j.seppu r.2011.04.017 open in new tab
  51. Chen H, Hu X, Chen E et al (2016) Preparation, characterization, and properties of chitosan films with cinnamaldehyde nanoemulsions. Food Hydrocoll 61:662-671. https :// foodh yd.2016.06.034 open in new tab
  52. Smith BC (2016) Group wavenumbers and an introduction to the spectroscopy of benzene rings. Spectroscopy 31:34-37
  53. Cristina A, Souza D, Dias AMA et al (2014) Impregnation of cinnamaldehyde into cassava starch biocomposite films using supercritical fluid technology for the development of food active packaging. Carbohydr Polym 102:830-837. https :// ol.2013.10.082 open in new tab
  54. Otoni CG, De Moura MR, Aouada FA et al (2014) Food hydrocolloids antimicrobial and physi- cal-mechanical properties of pectin/papaya puree/cinnamaldehyde nanoemulsion edible compos- ite films. Food Hydrocoll 41:188-194. https :// yd.2014.04.013 open in new tab
  55. Gao H (2017) Characteristics of poly vinyl alcohol films crosslinked by cinnamaldehyde with improved transparency and water resistance. J Appl Polym Sci 24:1-8. https :// app.45324 open in new tab
  56. Then C, Stassen B, Depta K, Silber G (2017) New methodology for mechanical characterization of human superficial facial tissue anisotropic behaviour in vivo. J Mech Behav Biomed Mater 71:68-79. https :// .2017.02.022 open in new tab
  57. Brostow W, Hagg Lobland HE, Narkis M (2006) Sliding wear, viscoelasticity, and brittleness of polymers. J Mater Res 21:2422-2428. https :// open in new tab
  58. Brostow W, Lobland HEH, Narkis M (2011) The concept of materials brittleness and its applica- tions. Polym Bull 67:1697-1707. https :// 9-011-0573-1 open in new tab
  59. Brostow W, Hagg Lobland HE (2010) Brittleness of materials: implications for composites and a relation to impact strength. J Mater Sci 45:242-250. https :// 3-009-3926-5 open in new tab
  60. Ma L, Gao C, Mao Z et al (2003) Collagen/chitosan porous scaffolds with improved biostability for skin tissue engineering. Biomaterials 24:4833-4841. https :// -9612(03)00374 -0 open in new tab
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