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Abstract
Hydrogels are three-dimensional polymer networks with hydrophilic properties. The modifiable properties of hydrogels and the structure resembling living tissue allow their versatile application. Therefore, increasing attention is focused on the use of hydrogels as bioinks for three-dimensional (3D) printing in tissue engineering. Bioprinting involves the fabrication of complex structures from several types of materials, cells, and bioactive compounds. Stem cells (SC), such as mesenchymal stromal cells (MSCs) are frequently employed in 3D constructs. SCs have desirable biological properties such as the ability to differentiate into various types of tissue and high proliferative capacity. Encapsulating SCs in 3D hydrogel constructs enhances their reparative abilities and improves the likelihood of reaching target tissues. In addition, created constructs can simulate the tissue environment and mimic biological signals. Importantly, the immunogenicity of scaffolds is minimized through the use of patient-specific cells and the biocompatibility and biodegradability of the employed biopolymers. Regenerative medicine is taking advantage of the aforementioned capabilities in regenerating various tissues muscle, bones, nerves, heart, skin, and cartilage.
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Authors (6)
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Milena Deptuła
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Małgorzata Zawrzykraj mgr
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Justyna Sawicka
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Michał Pikuła dr hab. med.
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.biopha.2023.115416
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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BIOMEDICINE & PHARMACOTHERAPY
no. 167,
ISSN: 0753-3322 - Language:
- English
- Publication year:
- 2023
- Bibliographic description:
- Deptuła M., Zawrzykraj M., Sawicka J., Banach-Kopeć A., Tylingo R., Pikuła M.: Application of 3D- printed hydrogels in wound healing and regenerative medicine// BIOMEDICINE & PHARMACOTHERAPY -, (2023),
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.biopha.2023.115416
- Sources of funding:
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- the National Science Centre [grant number 2020/04/X/ST5/01490], the Ministry of Science and Higher Education [Innovation Incubator 4.0, grant number 12/2020/II4.0], National Centre for Research and Development (grant number TECHMATSTRATEG2/410747/11/2019)
- Verified by:
- Gdańsk University of Technology
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