BACTERIAL INACTIVATION VIA LASER-DRIVEN GOLD NANOPARTICLE HEATING: SIMULATION AND ANALYSIS

Paweł Ziółkowski; Aimad Koulali; Piotr Radomski; Daniela De Biase; Federica Zaccagnini; Jacek Zieliński; Michał Pikuła; Kwang-un Jeong; Francesca Petronella; Luciano De Sio; Dariusz Mikielewicz

doi:10.1615/tfec2024.bio.051260

BACTERIAL INACTIVATION VIA LASER-DRIVEN GOLD NANOPARTICLE HEATING: SIMULATION AND ANALYSIS

Abstract

This study utilizes CFD technique to simulate the inactivation of E. coli bacteria within a microfluidic chamber, employing gold nanoparticles irradiated by a laser beam. Employing a single-phase model, the presence of bacteria is considered by treating thermal properties in the governing equations as effective, combining those of water and bacteria using established correlations from scientific literature. The conversion of light into heat is modeled with parameters derived from scientific literature, featuring a defined source term quantifying the converted light into heat. Introducing a User Defined Scalar (UDS) employing a first-order kinetic model described by the Arrhenius equation for the decay coefficient captures the bacteria's response to irradiation. A dedicated User Defined Function (UDF) is developed to implement this model, allowing the simulation to account for the reduction in bacterial concentration over time. The results uncover intricate dynamics in bacterial response to laser-induced thermal effects, showcasing the potential for effective bacterial control. Furthermore, the model is rigorously validated against experimental data, affirming its accuracy and robustness in reproducing real-world thermal effects.

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Authors (11)

Paweł Ziółkowski dr inż.
Aimad Koulali dr
Piotr Radomski mgr inż.
Daniela De Biase prof
- Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of Rome, Latina, Italy
Federica Zaccagnini
- Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of Rome, Latina, Italy
Jacek Zieliński dr hab.
- Medical University of Gdansk, Gdansk, Poland
Michał Pikuła Prof. dr hab.
- Medical University of Gdansk, Gdansk, Poland
Kwang-un Jeong
- Department of Polymer-Nano Science and Technology, Department of Nano Convergence Engineering, Jeonbuk National University, Jeonju, Republic of Korea
Francesca Petronella
- National Research Council of Italy, Institute of Crystallography CNR-IC, Montelibretti, Italy
Luciano De Sio prof.
- Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of Rome, Latina, Italy
Dariusz Mikielewicz prof. dr hab. inż.

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Publication version: Submitted Version
DOI:: Digital Object Identifier (open in new tab) 10.1615/TFEC2024.bio.051260
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Conference activity

Type:

publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)

Language:

English

Publication year:

2024

Bibliographic description:

Ziółkowski P., Koulali A., Radomski P., De Biase D., Zaccagnini F., Zieliński J., Pikuła M., Jeong K., Petronella F., De Sio L., Mikielewicz D.: BACTERIAL INACTIVATION VIA LASER-DRIVEN GOLD NANOPARTICLE HEATING: SIMULATION AND ANALYSIS// / : , 2024,

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