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Biocompatibility and bioactivity of load-bearing metallic implants

Abstract

The main objective of here presented research is to develop the titanium (Ti) alloy base composite materials possessing better biocompatibility, longer lifetime and bioactivity behaviour for load-bearing implants, e.g. hip joint and knee joint endoprosthesis. The development of such materials is performed through: modeling the material behaviour in biological environment in long time and developing of new procedures for such evaluation; obtaining of a Ti alloy with designed porosity; developing of an oxidation technology resulting in high corrosion resistance and bioactivity; developing of technologies for hydroxyapatite (HA) deposition aimed at composite bioactive coatings; developing of technologies of precipitation of the biodegradable core material placed within the pores.The examinations of degradation of Ti implants are carried out in order to recognize the sources of both early allergies and inflammation, and of long term degradation. The theoretical assessment of corrosion is made assuming three processes: electrochemical dissolution through imperfections of the anodic oxide layer, diffusion of metallic ions through the oxide layer, and dissolution of oxides themselves.In order to increase the biocompatibility, the toxic elements, aluminium (Al) and vanadium (V) are eliminated. The experiments have shown that titanium - zirconium - niobium (Ti-Zr-Nb) alloy may be a such a material which can also be prepared by both powder metallurgy (P/M) technique and selective laser melting. The porous (scaffold) Ti-Zr-Nb alloy is now obtained by powder metallurgy, classical and with space holders used before melting and decomposed, or remained during melting and removed by subsequent water dissolution. The oxidation of porous materials is performed either by electrochemical technique in special electrolytes or by chemical and/or hydrothermal method in order to obtain the optimal oxide layer well adjacent to an interface, preventing the base metal against corrosion and bioactive because of its nanotubular structure, permitting injection of some species into the pores. The Ca, O and N ion implantation or deposition of zirconia sublayers may be used to increase the biocompatibility, bioactivity and corrosion resistance. The HA coating obtained by either electrophoretic, biomimetic or by sol-gel deposition should result in gradient structure similar to bone structure, possessing high adhesion strength. The core material of the porous material should result in a biodegradable material, allowing slower dissolution followed by stepwise growth of bone tissue and angiogenesis, preventing local inflammation processes, sustaining the mechanical strength close to that of non-porous material.

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DOI:
Digital Object Identifier (open in new tab) 10.2478/v10077-010-0013-1
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Category:
Articles
Type:
artykuły w czasopismach recenzowanych i innych wydawnictwach ciągłych
Published in:
Advances in Materials Science no. 10, pages 21 - 31,
ISSN: 1730-2439
Language:
English
Publication year:
2010
Bibliographic description:
Zieliński A., Sobieszczyk S., Seramak T., Serbiński W., Świeczko-Żurek B., Ossowska A.: Biocompatibility and bioactivity of load-bearing metallic implants // Advances in Materials Science. -Vol. 10., nr. iss. 4 (2010), s.21-31
DOI:
Digital Object Identifier (open in new tab) 10.2478/v10077-010-0013-1
Verified by:
Gdańsk University of Technology

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