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Biological and mechanical properties of bone cement with nanoarticles - in vitro and in vivo research
Abstract
Despite antibiotic preventive treatment both before and after implant implementation, the risks of infection are real. These infections develop at the implant surface a few months after inserting them into the body. To prevent the development of bacteria and reduce the risk of infection, implants coated with nanoparticles are used. The Mechanical Department of the Technical University of Gdansk carries out research into using bone cement and metal nanoparticles as an alternative to antibiotics [1-3]. Until now, bone cement has been used without a supplement or with one or two drugs. These new experiments included pure bone cement with nanometals, without drugs. The titanium specimens were covered with nanometal coatings. Specimens were inserted into a rat`s thigh for six weeks. The implant was then removed from the body and examined by scanning electron microscope. The results were positive: there was a good adhesion of osteoblasts on the implant surface and there were no traces of infection. Biological research was also carried out. Boneless samples were placed into a bacterial liquid generated by the researcher which contained the five most common bacteria in the human body (Patent no. P409082). Mechanical and corrosion research was carried out at the same time. This confirmed that the modification of bone cement using nanometals has no significant negative effect on the setting time of bone cement, or on the hardness and value of contact angle. In addition, the bone cement coating (with or without nanometals) improved corrosion resistance.
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Authors (8)
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Anita Kajzer dr inż
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Wojciech Kajzer
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Karolina Siwicka
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Antonio Ramos
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Michel Mesnard Prof
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Jean-marc Olive Dr hab.
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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Journal of Mechanical Engineering and Biomechanics
no. 4,
pages 116 - 124,
ISSN: 2456-219X - Language:
- English
- Publication year:
- 2020
- Bibliographic description:
- Świeczko-Żurek B., Wekwejt M., Kajzer A., Kajzer W., Siwicka K., Ramos A., Mesnard M., Olive J.: Biological and mechanical properties of bone cement with nanoarticles - in vitro and in vivo research// Journal of Mechanical Engineering and Biomechanics -Vol. 4,iss. 5 (2020), s.116-124
- DOI:
- Digital Object Identifier (open in new tab) 10.24243/jmeb/4.5.234_x
- Verified by:
- Gdańsk University of Technology
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