Bisphenol A analogues and metabolic syndrome in women with polycystic ovary syndrome - Publication - Bridge of Knowledge

Your account

login

Search

Bisphenol A analogues and metabolic syndrome in women with polycystic ovary syndrome

Abstract

Bisphenols (BPs) have become a chemical group of special interest due to their ability to interfere with the endocrine system and their ubiquitous presence in the environment. As some of them possess mild estrogenic and anti-androgenic effects, they might be associated with the diagnosis of polycystic ovary syndrome (PCOS). Acting on multiple tissues, BPs exposure may lead to metabolic derangements characteristic for metabolic syndrome (MetS). Therefore, the aim of this study was to determine the potential relationship between exposure to some BPA analogues and features of the MetS in women with PCOS. Serum BPE, BPC, BPG, BPM, BPP, BPZ, BPFL, and BPBP concentrations did not differ significantly between the PCOS (n = 135) and the control subjects (n = 104). However, women whose serum BPM and BPP concentrations were in the highest tertile were more likely to be diagnosed with PCOS (adjusted OR; [95%CI] 0.43; [0.20; 0.89], P < 0.001 and 0.56; [0.27; 0.96], P = 0.049, consequently). Serum concentrations of BPs were not associated with the MetS diagnosis in the PCOS group. There was a negative correlation between the concentrations of serum BPBP and total serum cholesterol (r = – 0.153; P = 0.019), BPE and serum testosterone (r = – 0.160; P = 0.014) as well as BPC and HDL-cholesterol (r = – 0.138; P = 0.036). There was a positive correlation between the concentrations of BPP and serum triglycerides (r = 0.138; P = 0.036). Our results point to the potential association between exposure to BPM, BPP, and the diagnosis of PCOS, along with the impact of BPBP, BPE, BPC, and BPP on the metabolic features of the MetS.

Citations

  • 0

    CrossRef

  • 0

    Web of Science

  • 1

    Scopus

Authors (8)

Cite as

Full text

download paper
downloaded 38 times
Publication version
Submitted Version
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.reprotox.2023.108511
License
Copyright (2023 Elsevier Inc.)

Keywords

Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
REPRODUCTIVE TOXICOLOGY no. 123,
ISSN: 0890-6238
Language:
English
Publication year:
2024
Bibliographic description:
Majewska J., Berg A., Jurewicz J., Owczarek K., Zajdel R., Kilanowicz A., Wasik A., Rachoń D.: Bisphenol A analogues and metabolic syndrome in women with polycystic ovary syndrome// REPRODUCTIVE TOXICOLOGY -Vol. 123, (2024), s.108511-
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.reprotox.2023.108511
Sources of funding:
  • 2014/15/B/NZ7/00999
Verified by:
Gdańsk University of Technology

seen 132 times

Recommended for you

Serum bisphenol A concentrations correlate with serum testosterone levels in women with polycystic ovary syndrome

2018

The potential role of bisphenol A in the pathogenesis of polycystic ovary syndrome

2014

Adipokine and cytokine levels in non-functioning adrenal incidentalomas (NFAI)

2018

Exposure to Bisphenol A Analogs and the Thyroid Function and Volume in Women of Reproductive Age—Cross-Sectional Study

  • J. Milczarek-Banach,
  • D. Rachoń,
  • T. Bednarczuk
  • + 3 authors
2021
Meta Tags