Cardinal regenerative features of the MRL mouse

L. Matthew Arthur; Paweł Sachadyn; Dmitri Gourevitch; Ellen Heber-Katz

Cardinal regenerative features of the MRL mouse

Abstract

In this review, we discuss recent studies relating to major features of adult MRL mouse biology that contribute to the regenerative responses seen. These include an increased inflammatory cell profile, a unique glycolytic metabolic state typically found during embryogenesis, and a cell cycle phenotype of DNA damage and G2/M arrest. These traits have been found in other mammalian and non-mammalian regenerative systems. How these physiological systems interact with each other and bring about regeneration is explored.

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Category:: Articles
Type:: artykuły w czasopismach
Published in:: Gene Therapy and Regulation no. 6, pages 51 - 70,
ISSN: 1388-9532
Language:: English
Publication year:: 2011
Bibliographic description:: Arthur L. M., Sachadyn P., Gourevitch D., Heber-Katz E.: Cardinal regenerative features of the MRL mouse// Gene Therapy and Regulation -Vol. 6,iss. 1 (2011), s.51-70
Verified by:: Gdańsk University of Technology