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Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors

Abstract

The chloroacridines affect biological forms of melanoma in different ways. Amelanotic (Ab) melanoma (with inhibited melanogenesis and higher malignancy) was particularly sensitive to the action of the chloroacridines. The Ab melanoma cells died through apoptosis and through death without caspase activation. Diminished activity of TAC enzymes was noticed among Ab melanoma cells together with ATP/NAD depletion, especially in the case of 1b. Our data show that the biological forms of the tumors responded to 1a and its 4-methylated analog in different ways. 1a and 1b could be inducers of regulated melanoma cell death, especially the amelanotic form. Although the mechanism of the cell death is not fully understood, 1b may act by interfering with the TAC enzymes and blocking specific pathways leading to tumor growth. This could encourage further investigation of its anticancer activity, especially against the amelanotic form of melanoma.

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
BIOMEDICINE & PHARMACOTHERAPY no. 130,
ISSN: 0753-3322
Language:
English
Publication year:
2020
Bibliographic description:
Cichorek M., Ronowska A., Dzierzbicka K., Gensicka-Kowalewska M., Deptuła M., Pelikant-Malecka I.: Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors// BIOMEDICINE & PHARMACOTHERAPY -Vol. 130, (2020), s.110515-
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.biopha.2020.110515
Verified by:
Gdańsk University of Technology

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