Ciprofloxacin-modified degradable hybrid polyurethane-polylactide porous scaffolds developed for potential use as an antibacterial scaffold for regeneration of skin - Publication - Bridge of Knowledge

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Ciprofloxacin-modified degradable hybrid polyurethane-polylactide porous scaffolds developed for potential use as an antibacterial scaffold for regeneration of skin

Abstract

The aim of the performed study was to fabricate an antibacterial and degradable scaffold that may be used in the field of skin regeneration. To reach the degradation criterion for the biocompatible polyurethane (PUR), obtained by using amorphous α,ω-dihydroxy(ethylene-butylene adipate) macrodiol (PEBA), was used and processed with so-called “fast-degradable” polymer polylactide (PLA) (5 or 10 wt %). To meet the antibacterial requirement obtained, hybrid PUR-PLA scaffolds (HPPS) were modified with ciprofloxacin (Cipro) (2 or 5 wt %) and the fluoroquinolone antibiotic inhibiting growth of bacteria, such as Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus, which are the main causes of wound infections. Performed studies showed that Cipro-modified HPPS, obtained by using 5% of PLA, possess suitable mechanical characteristics, morphology, degradation rates, and demanded antimicrobial properties to be further developed as potential scaffolds for skin tissue engineering.

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
Polymers no. 12, pages 1 - 18,
ISSN: 2073-4360
Language:
English
Publication year:
2020
Bibliographic description:
Carayon I., Terebieniec A., Łapiński M., Filipowicz N., Kucińska-Lipka J.: Ciprofloxacin-modified degradable hybrid polyurethane-polylactide porous scaffolds developed for potential use as an antibacterial scaffold for regeneration of skin// Polymers -Vol. 12,iss. 1 (2020), s.1-18
DOI:
Digital Object Identifier (open in new tab) 10.3390/polym12010171
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  1. Esteban-vives, R.; Young, M.T.; Ziembicki, J.; Corcos, A.; Gerlach, C. Effects of wound dressings on cultured primary keratinocytes. Burns 2016, 42, 81-90. [CrossRef] [PubMed] open in new tab
  2. Wohlsein, P.; Peters, M.; Schulze, C.; Baumga, W. Thermal Injuries in Veterinary Forensic Pathology. Vet. Pathol. 2016, 53, 1001-1017. [CrossRef] [PubMed] open in new tab
  3. Kim, M.; Evans, D. Tissue engineering: The future of stem cells. Top. Tissue Eng. 2005, 2, 1-22.
  4. Brekke, J.H.; Toth, J.M. Principles of tissue engineering applied to programmable osteogenesis. J. Biomed. Mater. Res. 1998, 43, 380-398. [CrossRef] open in new tab
  5. Gurtner, G.C.; Callaghan, M.J.; Longaker, M.T. Progress and potential for regenerative medicine. Annu. Rev. Med. 2007, 58, 299-312. [CrossRef] open in new tab
  6. Gurtner, G.C.; Werner, S.; Barrandon, Y.; Longaker, M.T. Wound repair and regeneration. Nature 2008, 453, 314. [CrossRef] open in new tab
  7. Feinberg, A.W. Engineered tissue grafts: Opportunities and challenges in regenerative medicine. Wiley Interdiscip. Rev. Syst. Biol. Med. 2012, 4, 207-220. [CrossRef] open in new tab
  8. Kucinska-Lipka, J.; Gubanska, I.; Janik, H.; Pokrywczynska, M.; Drewa, T. L-ascorbic acid modified poly(ester urethane)s as a suitable candidates for soft tissue engineering applications. React. Funct. Polym. 2015, 97, 105-115. [CrossRef] open in new tab
  9. Lipka, J.K.; Lewandowska, I.G.A. Antibacterial polyurethanes, modified with cinnamaldehyde, as potential materials for fabrication of wound dressings. In Polymer Bulletin; Springer: Berlin/Heidelberg, Germany, 2018.
  10. Kucińska-Lipka, J.; Gubanska, I.; Skwarska, A. Microporous polyurethane thin layer as a promising scaffold for tissue engineering. Polymers 2017, 9, 277. [CrossRef] [PubMed] open in new tab
  11. Heureux, L.; Fricain, J.; Catros, S.; Le Nihouannen, D. Characterization of printed PLA scaffolds for bone tissue engineering. J. Biolmed. Mater. Res. 2018, 106, 887-894.
  12. Li, L.; Li, Q.; Yang, J.; Sun, L.; Guo, J.; Yao, Y.; Zhong, L.; Li, D. Enhancement in mechanical properties and cell activity of polyurethane scaffold derived from gastrodin. Mater. Lett. 2018, 228, 435-438. [CrossRef] open in new tab
  13. Mi, H.; Jing, X.; Yu, E.; Wang, X.; Li, Q.; Turng, L. Manipulating the structure and mechanical properties of thermoplastic polyurethane/polycaprolactone hybrid small diameter vascular scaff olds fabricated via electrospinning using an assembled rotating collector. J. Mech. Behav. Biomed. Mater. 2018, 78, 433-441. [CrossRef] [PubMed] open in new tab
  14. Barnes, C.P.; Sell, S.A.; Boland, E.D.; Simpson, D.G.; Bowlin, G.L. Nanofiber technology: Designing the next generation of tissue engineering scaffolds. Adv. Drug Deliv. Rev. 2007, 59, 1413-1433. [CrossRef] [PubMed] open in new tab
  15. Gubanska, I.; Kucinska-Lipka, J.; Janik, H. The influence of amorphous macrodiol, diisocyanate type and L-ascorbic acid modifier on chemical structure, morphology and degradation behavior of polyurethanes for tissue scaffolds fabrication. In Polymer Degradation and Stability; open in new tab
  16. Mikos, A.G.; Herring, S.W.; Ochareon, P.; Elisseeff, J.; Lu, H.H.; Kandel, R.; Schoen, F.J.; Toner, M.; Mooney, D.; Atala, A.; et al. Engineering complex tissues. Tissue Eng. 2006, 12, 3307-3339. [CrossRef] [PubMed] open in new tab
  17. Palmiero, C.; Imparato, G.; Urciuolo, F.; Netti, P. Engineered dermal equivalent tissue in vitro by assembly of microtissue precursors. Acta Biomater. 2010, 6, 2548-2553. [CrossRef] open in new tab
  18. Urciuolo, F.; Imparato, G.; Totaro, A. Building a tissue in vitro from the bottom up: Implications in regenerative medicine. Methodist Debakey Cardiovasc. J. 2013, 9, 213-217. [CrossRef] open in new tab
  19. Fisher, M.B.; Mauck, R.L. Tissue Engineering and Regenerative Medicine: Recent Innovations and the Transition to Translation. Tissue Eng. Part B Rev. 2013, 19, 1-13. [CrossRef] open in new tab
  20. Dong, Z.; Li, Y.; Zou, Q. Degradation and biocompatibility of porous nano-hydroxyapatite/polyurethane composite scaffold for bone tissue engineering. Appl. Surf. Sci. 2009, 255, 6087-6091. [CrossRef] open in new tab
  21. Tatai, L.; Moore, T.G.; Adhikari, R. Thermoplastic biodegradable polyurethanes: The effect of chain extender structure on properties and in-vitro degradation. Biomaterials 2007, 28, 5407-5417. [CrossRef] open in new tab
  22. Bose, S.; Roy, M.; Bandyopadhyay, A. Recent advances in bone tissue engineering scaffolds. Trends Biotechnol. 2012, 30, 546-554. [CrossRef] open in new tab
  23. Liu, X.; Chen, W.; Gustafson, C.T.; Lee, A.; Ii, M.; Waletzki, B.E.; Yaszemski, M.J.; Lu, L. Tunable tissue sca ff olds fabricated by in situ crosslink in phase separation system. RSC Adv. R. Soc. Chem. 2015, 5, 100824-100833. [CrossRef] [PubMed] open in new tab
  24. Middleton, J.C.; Tipton, A.J. Synthetic biodegradable polymers as orthopedic devices. Biomaterials 2000, 21, 2335-2346. [CrossRef] open in new tab
  25. DW, H. scaffold-based bone engineering by using rapi prototyping technologies in virtual and rapid manufacturing. In Advanced Research in Virtual and Rapid Prototyping; Bartolo, J.B., Ed.; Taylor & Francis Group: Abingdon-on-Thames, UK, 2008; p. 65. open in new tab
  26. Guelcher, S.A.; Srinivasan, A.; Dumas, J.E.; Didier, J.E.; McBride, S.; Hollinger, J.O. Synthesis, mechanical properties, biocompatibility, and biodegradation of polyurethane networks from lysine polyisocyanates. Biomaterials 2008, 29, 1762-1775. [CrossRef] [PubMed] open in new tab
  27. Montini-Ballarin, F.; Caracciolo, P.C.; Rivero, G.; Abraham, G.A. In vitro degradation of electrospun poly(l-lactic acid)/segmented poly(ester urethane) blends. Polym. Degrad. Stab. 2016, 126, 159-169. [CrossRef] open in new tab
  28. Ballarin, F.M.; Caracciolo, P.C.; Blotta, E.; Ballarin, V.L.; Abraham, G.A. Optimization of poly(L-lactic acid)/segmented polyurethane electrospinning process for the production of bilayered small-diameter nano fi brous tubular structures. Mater. Sci. Eng. C 2014, 42, 489-499. [CrossRef] open in new tab
  29. Gudiño-rivera, J.; Medellín-rodríguez, F.J.; Ávila-orta, C.; Palestino-escobedo, A.G.; Sánchez-valdés, S. Structure/property relationships of poly(L-lactic acid)/mesoporous silica nanocomposites. J. Polym. 2013, 2013. [CrossRef] open in new tab
  30. Ulery, B.D.; Nair, L.S.; Laurencin, C.T. Biomedical Applications of Biodegradable Polymers. J. Polym. Sci. Part. B Polym. Phys. 2011, 49, 832-864. [CrossRef] open in new tab
  31. Lipsa, R.; Tudorachi, N.; Vasile, C. Poly(α-hydroxyacids ) in biomedical applications: Synthesis and properties of lactic acid polymers. e-Polymers 2010, 10. [CrossRef] open in new tab
  32. Lasprilla, A.J.R.; Martinez, G.A.R.; Lunelli, B.H.; Jardini, A.L.; Maciel, R. Poly-lactic acid synthesis for application in biomedical devices-A review. Biotechnol. Adv. 2012, 30, 321-328. [CrossRef] open in new tab
  33. Vats, A.; Tolley, Ã.N.S.; Polak, J.M.Ã.; Gough, J.E.Ã. Scaffolds and biomaterials for tissue engineering: A review of clinical applications. Clin. Otolaryngol. Allied Sci. 2003, 28, 165-172. [CrossRef] [PubMed] open in new tab
  34. Elsawy, M.A.; Kim, K.; Park, J.; Deep, A. Hydrolytic degradation of polylactic acid(PLA) and its composites. Renew. Sustain. Energy Rev. 2017, 79, 1346-1352. [CrossRef] open in new tab
  35. Adhikari, R.; Scientific, T.C. Biodegradable polyurethanes: Design, synthesis, properties and potential applications. In Biodegradable Polymers: Processing, Degradation and Applications; Nova Science Publishers: Hauppauge, NY, USA, 2011; pp. 431-470.
  36. Guelcher, S.A. Biodegradable polyurethanes: Synthesis and applications in regenerative medicine. Tissue Eng. Part. B Rev. 2008, 14, 11-19. [CrossRef] open in new tab
  37. Mogensen, T.H. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin. Microbiol. Rev. 2009, 22, 240-273. [CrossRef] [PubMed] open in new tab
  38. Chen, L.; Deng, H.; Cui, H.; Fang, J.; Zuo, Z. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget 2018, 9, 7204-7218. [CrossRef] [PubMed] open in new tab
  39. Guo, S.; Dipietro, L.A. Factors affecting wound healing. J. Dent. Res. 2010, 89, 219-229. [CrossRef] open in new tab
  40. Kwok, C.S.; Wan, C.; Hendricks, S.; Bryers, J.D.; Horbett, T.A.; Ratner, B.D. Design of infection-resistant antibiotic-releasing polymers: I. fabrication and formulation. J. Control. Release 1999, 62, 289-299. [CrossRef] open in new tab
  41. Field, K.; Kerstein, M.D. Overview of wound healing in a moist environment. Am. J. Surg. 1994, 167, 2-6. [CrossRef] open in new tab
  42. Anjum, S.; Arora, A.; Alam, M.S.; Gupta, B. Development of antimicrobial and scar preventive chitosan hydrogel wound dressings. Int. J. Pharm. 2016, 508, 92-101. [CrossRef] [PubMed] open in new tab
  43. Vowden, K. Wound dressings: Principles and practice. In Surgery; Elsevier Ltd.: Amsterdam, The Netherlands, 2017; pp. 1-6. open in new tab
  44. Koosehgol, S.; Ebrahimian-hosseinabadi, M.; Alizadeh, M.; Zamanian, A. Preparation and characterization of in situ chitosan/polyethylene glycol fumarate/thymol hydrogel as an effective wound dressing. Mater. Sci. Eng. C 2017, 79, 66-75. [CrossRef] [PubMed] open in new tab
  45. Yari, A.; Yeganeh, H.; Bakhshi, H. Synthesis and evaluation of novel absorptive and antibacterial polyurethane membranes as wound dressing. J. Mater. Sci. Mater. Med. 2012, 23, 2187-2202. [CrossRef] [PubMed] open in new tab
  46. Bergamo, R.; Buzatto, C.; Alberto, J.; Maria, Â. Electrospun multilayer chitosan scaffolds as potential wound dressings for skin lesions. Eur. Polym. J. 2017, 88, 161-170.
  47. Sikareepaisan, P.; Ruktanonchai, U.; Supaphol, P. Preparation and characterization of asiaticoside-loaded alginate films and their potential for use as effectual wound dressings. Carbohydr. Polym. 2011, 83, 1457-1469. [CrossRef] open in new tab
  48. Unnithan, A.R.; Barakat, N.A.M.; Pichiah, P.B.T.; Gnanasekaran, G.; Nirmala, R.; Cha, Y.; Jung, C.H.; El-Newehy, M.; Kim, H.Y. Wound-dressing materials with antibacterial activity from electrospun polyurethane-dextran nanofiber mats containing ciprofloxacin HCl. Carbohydr. Polym. 2012, 90, 1786-1793. [CrossRef] [PubMed] open in new tab
  49. Nagarwal, R.C.; Kant, S.; Singh, P.N.; Maiti, P.; Pandit, J.K. Polymeric nanoparticulate system: A potential approach for ocular drug delivery. J. Control. Release 2009, 136, 2-13. [CrossRef] [PubMed] open in new tab
  50. Sinha, M.; Banik, R.M. Development of ciprofloxacin hydrochloride loaded poly(ethylene glycol)/chitosan scaffold as wound dressing. J. Porous Mater. 2013, 20, 799-807. [CrossRef] open in new tab
  51. Bergman, B.; Bishop, M.C.; Bjerklund-johansen, T.E.; Botto, H.; Lobel, B.; Cruz, F.J.; Selvaggi, F.P. EAU guidelines for the management of urinary and male genital tract infectionstextsuperscript1. Eur. Urol. 2001, 40, 576-588.
  52. Zeiler, H.; Grohe, K.; Ag, B.; Ciprofloxacin, A.A. the in vitro and in vivo activity of ciprofloxacin. In Ciprofloxacin; Vieweg+Teubner Verlag: Wiesbaden, Germany, 1986; pp. 14-18. open in new tab
  53. Dillen, K.; Vandervoort, J.; Van Den Mooter, G.; Verheyden, L.; Ludwig, A. Factorial design, physicochemical characterisation and activity of ciprofloxacin-PLGA nanoparticles. Int. J. Pharm. 2004, 275, 171-187. [CrossRef] open in new tab
  54. Page, J.M.; Prieto, E.M.; Dumas, J.E.; Zienkiewicz, K.J.; Wenke, J.C.; Brown-Baer, P.; Guelcher, S.A. Biocompatibility and chemical reaction kinetics of injectable, settable polyurethane/allograft bone biocomposites. Acta Biomater. 2012, 8, 4405-4416. [CrossRef] open in new tab
  55. Bessa, L.J.; Fazii, P.; Di Giulio, M.; Cellini, L. Bacterial isolates from infected wounds and their antibiotic susceptibility pattern: Some remarks about wound infection. Int. Wound J. 2015, 12, 47-52. [CrossRef] open in new tab
  56. Boffito, M.; Sartori, S.; Ciardelli, G. Polymeric scaffolds for cardiac tissue engineering: Requirements and fabrication technologies. Polym. Int. 2014, 63, 2-11. [CrossRef] open in new tab
  57. Janik, H.; Marzec, M. A review: Fabrication of porous polyurethane scaffolds. Mater. Sci. Eng. C 2015, 48, 586-591. [CrossRef] [PubMed] open in new tab
  58. Silvestri, A.; Boffito, M.; Sartori, S.; Ciardelli, G. Biomimetic materials and scaffolds for myocardial tissue regeneration. Macromol. Biosci. 2013, 13, 984-1019. [CrossRef] open in new tab
  59. Stachelek, S.J.; Alferiev, I.; Ueda, M.; Eckels, E.C.; Kevin, T.; Levy, R.J. Prevention of polyurethane oxidative degradation with phenolic-antioxidants covalently attached to the hard segments: Structure function. J. Biomed. Mater. Res. Part. A 2010, 94, 751-759. [CrossRef] [PubMed] open in new tab
  60. Cetina-Diaz, S.M.; Chan-Chan, L.H.; Vargas-Coronado, R.F.; Cervantes-Uc, J.M.; Quintana-Owen, P.; Paakinaho, K.; Kellomaki, M.; Silvio, L.D.; Deb, S.; Cauich-Rodríguez, J.V. Physicochemical characterization of segmented polyurethanes prepared with glutamine or ascorbic acid as chain extenders and their hydroxyapatite composites. J. Mater. Chem. B 2014, 2, 1966-1976. [CrossRef] open in new tab
  61. Tan, Z.; Tan, F.; Zhao, L.; Li, J. The Synthesis, Characterization and Application of Ciprofloxacin Complexes and Its Coordination with Copper, Manganese and Zirconium Ions. J. Cryst. Process Technol. 2012, 2, 55-63. [CrossRef] open in new tab
  62. Yilgor, I.; Yilgor, E.; Guler, I.G.; Ward, T.C.; Wilkes, G.L. FTIR investigation of the influence of diisocyanate symmetry on the morphology development in model segmented polyurethanes. Polymer 2006, 47, 4105-4114. [CrossRef] open in new tab
  63. Doolittle, J.; Su, H.-C.; Khatun, J.; Secrest, A.; Clark, M.; Ramkissoon, K.; Wolfgang, M.C.; Giddings, M.C. The development of ciprofloxacin resistance in pseudomonas aeruginosa involves multiple response stages and multiple proteins. Antimicrob. Agents Chemother. 2010, 54, 4626-4635.
  64. Kucinska-Lipka, J.; Gubanska, I.; Sienkiewicz, M. Thermal and mechanical properties of polyurethanes modified with L-ascorbic acid. J. Therm. Anal. Calorim. 2017, 127, 1631-1638. [CrossRef] open in new tab
  65. Diridollou, S.; Patat, F.; Gens, F.; Vaillant, L.; Black, D.; Lagarde, J.M.; Gall, Y.; Berson, M. In vivo model of the mechanical properties of the human skin under suction. Skin Res. Technol. 2000, 6, 214-221. [CrossRef] open in new tab
  66. Gallagher, A.J.; Ní Anniadh, A.; Bruyère, K.; Otténio, M.; Xie, H.; Gilchrist1, M.D. Dynamic tensile properties of human skin. In Proceedings of the 2012 IRCOBI Conference International Research Council on the Biomechanics of Injury, Dublin, Ireland, 12-14 Sepember 2012; pp. 494-502.
  67. Kucińska-Lipka, J.; Gubańska, I.; Janik, H. Gelatin-modified polyurethanes for soft tissue scaffold. Sci. World J. 2013, 2013. [CrossRef] open in new tab
  68. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). open in new tab
Sources of funding:
  • This work was supported by the Gdansk University of Technology, Narutowicza St. 11/12, 80-233 Gdansk, Poland, Internal Funding No. 033206
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Gdańsk University of Technology

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