Closed-loop stimulation of temporal cortex rescues functional networks and improves memory - Publication - MOST Wiedzy

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Closed-loop stimulation of temporal cortex rescues functional networks and improves memory

Abstract

Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often target the hippocampus and medial temporal lobes. Here we use a closed-loop system to monitor and decode neural activity from direct brain recordings in humans. We apply targeted stimulation to lateral temporal cortex and report that this stimulation rescues periods of poor memory encoding. This system also improves later recall, revealing that the lateral temporal cortex is a reliable target for memory enhancement. Taken together, our results suggest that such systems may provide a therapeutic approach for treating memory dysfunction.

Citations

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Authors

  • Photo of  Youssef Ezzyat

    Youssef Ezzyat

  • Photo of  Paul A. Wanda

    Paul A. Wanda

  • Photo of  Deborah F. Levy

    Deborah F. Levy

  • Photo of  Allison Kadel

    Allison Kadel

  • Photo of  Ada Aka

    Ada Aka

  • Photo of  Isaac Pedisich

    Isaac Pedisich

  • Photo of  Michael R. Sperling

    Michael R. Sperling

  • Photo of  Ashwini Sharan

    Ashwini Sharan

  • Photo of  Bradley C. Lega

    Bradley C. Lega

  • Photo of  Alexis Burks

    Alexis Burks

  • Photo of  Robert E. Gross

    Robert E. Gross

  • Photo of  Cory S. Inman

    Cory S. Inman

  • Photo of  Barbara C. Jobst

    Barbara C. Jobst

  • Photo of  Mark A. Gorenstein

    Mark A. Gorenstein

  • Photo of  Kathryn A. Davis

    Kathryn A. Davis

  • Photo of  Gregory A. Worrell

    Gregory A. Worrell

  • Photo of  Joel M. Stein

    Joel M. Stein

  • Photo of  Richard Gorniak

    Richard Gorniak

  • Photo of  Sandhitsu R. Das

    Sandhitsu R. Das

  • Photo of  Daniel S. Rizzuto

    Daniel S. Rizzuto

  • Photo of  Michael J. Kahana

    Michael J. Kahana

Details

Category:
Magazine publication
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
Nature Communications no. 9, pages 1 - 8,
ISSN: 2041-1723
Language:
English
Publication year:
2018
Bibliographic description:
Ezzyat Y., Wanda P., Levy D., Kadel A., Aka A., Pedisich I., Sperling M., Sharan A., Lega B., Burks A., Gross R., Inman C., Jobst B., Gorenstein M., Davis K., Worrell G., Kucewicz M., Stein J., Gorniak R., Das S., Rizzuto D., Kahana M.: Closed-loop stimulation of temporal cortex rescues functional networks and improves memory// Nature Communications. -Vol. 9, (2018), s.1-8
DOI:
Digital Object Identifier (open in new tab) 10.1038/s41467-017-02753-0
Verification:
Gdańsk University of Technology

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