Search
Abstract
Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often target the hippocampus and medial temporal lobes. Here we use a closed-loop system to monitor and decode neural activity from direct brain recordings in humans. We apply targeted stimulation to lateral temporal cortex and report that this stimulation rescues periods of poor memory encoding. This system also improves later recall, revealing that the lateral temporal cortex is a reliable target for memory enhancement. Taken together, our results suggest that such systems may provide a therapeutic approach for treating memory dysfunction.
Citations
-
2 3 7
CrossRef
-
0
Web of Science
-
1 8 7
Scopus
Authors (22)
-
Youssef Ezzyat
- University of Pennsylvania Department of Psychology
-
Paul A. Wanda
- University of Pennsylvania Department of Psychology
-
Deborah F. Levy
- University of Pennsylvania Department of Psychology
-
Allison Kadel
- University of Pennsylvania Department of Psychology
-
Ada Aka
- University of Pennsylvania Department of Psychology
-
Isaac Pedisich
- University of Pennsylvania Department of Psychology
-
Michael R. Sperling
- Thomas Jefferson University Hospital Deparment of Neurology
-
Ashwini Sharan
- Thomas Jefferson University Hospital Department of Neurosurgery
-
Bradley C. Lega
- University of Texas Department of Neurosurgery
-
Alexis Burks
- University of Texas Department of Neurosurgery
-
Robert E. Gross
- Emory University Hospital, Department of Neurosurgery
-
Cory S. Inman
- Emory University Hospital Department of Neurosurgery
-
Barbara C. Jobst
- Dartmouth-Hitchcock Medical Center Department of Neurology
-
Mark A. Gorenstein
- Dartmouth-Hitchcock Medical Center Department of Neurology
-
Kathryn A. Davis
- Hospital of the University of Pennsylvania Department of Neurology
-
Gregory A. Worrell
- Mayo Clinic Department of Neurology
-
Joel M. Stein
- Hospital of the University of Pennsylvania Department of Radiology
-
Richard Gorniak
- Thomas Jefferson University Hospital Department of Radiology
-
Sandhitsu R. Das
- Hospital of the University of Pennsylvania Department of Neurology
-
Daniel S. Rizzuto
- University of Pennsylvania Department of Psychology
-
Michael J. Kahana
- University of Pennsylvania Department of Psychology
Cite as
Full text
- Publication version
- Accepted or Published Version
- License
-
open in new tab
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
Nature Communications
no. 9,
pages 1 - 8,
ISSN: 2041-1723 - Language:
- English
- Publication year:
- 2018
- Bibliographic description:
- Ezzyat Y., Wanda P. A., Levy D. F., Kadel A., Aka A., Pedisich I., Sperling M. R., Sharan A., Lega B. C., Burks A., Gross R. E., Inman C. S., Jobst B. C., Gorenstein M. A., Davis K. A., Worrell G. A., Kucewicz M. T., Stein J. M., Gorniak R., Das S. R., Rizzuto D. S., Kahana M. J.: Closed-loop stimulation of temporal cortex rescues functional networks and improves memory// Nature Communications. -Vol. 9, (2018), s.1-8
- DOI:
- Digital Object Identifier (open in new tab) 10.1038/s41467-017-02753-0
- Verified by:
- Gdańsk University of Technology
seen 192 times
Recommended for you
Human memory enhancement through electrical stimulation in the temporal cortex
- M. T. Kucewicz,
- B. M. Berry,
- L. R. Miller
- + 17 authors
Direct brain stimulation modulates encoding states and memory performance in humans
- Y. Ezzyat,
- J. E. Kragel,
- J. F. Burke
- + 23 authors