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Comparison of the paracetamol electrochemical determination using boron-doped diamond electrode and boron-doped carbon nanowalls
Abstract
Two different type of electrodes, boron-doped diamond electrode (BDD) and boron-doped carbon nanowalls (B:CNW) electrode, were used for the electrochemical determination of paracetamol using the cyclic voltammetry and the differential pulse voltammetry in phosphate buffered saline, pH = 7.0. The main advantage of these electrodes is their utilization without any additional modification of the electrode surface. The peak current was linearly related to the concentration of paracetamol in the range from 0.065 µM to 32 µM for BDD electrode and from 0.032 µM to 32 µM for B:CNW electrode. The limit of detection was 0.430 µM and 0.281 µM for BDD and B:CNW electrode, respectively. Additionally, we studied the effect of pH on the redox reaction of paracetamol at the both electrodes in Britton-Robinson buffer solution in the range of pH 3.0–12.0, indicating the pH 7.0 value as the most suitable for the current experiments. The studies also included the various scan rates in range of 50–500 mV/s. Finally, our team selected the B:CNW electrode for the determination of paracetamol in the artificial urine sample using differential pulse voltammetry method, obtaining the calculated limit of detection on the level of 0.08006 µM.
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Authors (9)
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Paweł Niedziałkowski Dr
- Uniwersytet Gdański Chemii Analitycznej
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Zofia Celuba
- Uniwersytet Gdański Chemii Analitycznej
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Natalia Malinowska
- Uniwersytet Gdański Chemii Analitycznej
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Wioleta Białobrzeska mgr inż.
- Uniwersytet Gdański Chemii Analitycznej
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Jacek Sein Anand dr hab. med.
- Gdański Uniwersytet Medyczny Zakład Toksykologii Klinicznej
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Tadeusz Ossowski prof. dr hab. inż.
- Uniwersytet Gdański Chemii Analitycznej
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.bios.2018.10.063
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
BIOSENSORS & BIOELECTRONICS
no. 126,
pages 308 - 314,
ISSN: 0956-5663 - Language:
- English
- Publication year:
- 2019
- Bibliographic description:
- Niedziałkowski P., Celuba Z., Malinowska N., Białobrzeska W., Sobaszek M., Ficek M., Bogdanowicz R., Anand J. S., Ossowski T.: Comparison of the paracetamol electrochemical determination using boron-doped diamond electrode and boron-doped carbon nanowalls// BIOSENSORS & BIOELECTRONICS. -Vol. 126, (2019), s.308-314
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.bios.2018.10.063
- Verified by:
- Gdańsk University of Technology
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