Comprehensive Evaluation of the Biological Properties of Surface-Modified Titanium Alloy Implants - Publication - MOST Wiedzy

Search

Comprehensive Evaluation of the Biological Properties of Surface-Modified Titanium Alloy Implants

Abstract

An increasing interest in the fabrication of implants made of titanium and its alloys results from their capacity to be integrated into the bone system. This integration is facilitated by different modifications of the implant surface. Here, we assessed the bioactivity of amorphous titania nanoporous and nanotubular coatings (TNTs), produced by electrochemical oxidation of Ti6Al4V orthopedic implants’ surface. The chemical composition and microstructure of TNT layers was analyzed by X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). To increase their antimicrobial activity, TNT coatings were enriched with silver nanoparticles (AgNPs) with the chemical vapor deposition (CVD) method and tested against various bacterial and fungal strains for their ability to form a biofilm. The biointegrity and anti-inflammatory properties of these layers were assessed with the use of fibroblast, osteoblast, and macrophage cell lines. To assess and exclude potential genotoxicity issues of the fabricated systems, a mutation reversal test was performed (Ames Assay MPF, OECD TG 471), showing that none of the TNT coatings released mutagenic substances in long-term incubation experiments. The thorough analysis performed in this study indicates that the TNT5 and TNT5/AgNPs coatings (TNT5—the layer obtained upon applying a 5 V potential) present the most suitable physicochemical and biological properties for their potential use in the fabrication of implants for orthopedics. For this reason, their mechanical properties were measured to obtain full system characteristics.

Citations

  • 4

    CrossRef

  • 3

    Web of Science

  • 0

    Scopus

Authors (10)

Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
Journal of Clinical Medicine no. 9, pages 1 - 29,
ISSN: 2077-0383
Language:
English
Publication year:
2020
Bibliographic description:
Piszczek P., Radtke A., Ehlert M., Jędrzejewski T., Sznarkowska A., Sadowska B., Bartmański M., Erdogan Y., Ercan B., Jędrzejczyk W.: Comprehensive Evaluation of the Biological Properties of Surface-Modified Titanium Alloy Implants// Journal of Clinical Medicine -Vol. 9,iss. 2 (2020), s.1-29
DOI:
Digital Object Identifier (open in new tab) 10.3390/jcm9020342
Bibliography: test
  1. Buser, D.; Sennerby, L.; De Bruyn, H. Modern implant dentistry based on osseointegration: 50 years of progress, current trends and open questions. Periodontology 2000 2017, 73, 7-21. [CrossRef] open in new tab
  2. Scholz, M.-S.; Blanchfield, J.P.; Bloom, L.D.; Coburn, B.H.; Elkington, M.; Fuller, J.D.; Gilbert, M.E.; Muflahi, S.A.; Pernice, M.F.; Rae, S.I.; et al. The use of composite materials in modern orthopaedic medicine and prosthetic devices: A review. Compos. Sci. Technol. 2011, 71, 1791-1803. [CrossRef] open in new tab
  3. Cronskär, M.; Lars-Erik Rännar, L.-E.; Bäckström, M. Implementation of Digital Design and Solid Free-Form Fabrication for Customization of Implants in Trauma Orthopaedics. J. Med. Biol. Eng. 2010, 32, 91-96. [CrossRef] open in new tab
  4. Lim, K.M.; Park, J.W.; Park, S.J.; Kang, H.K. 3D-Printed Personalized Titanium Implant Design,Manufacturing and Verification for Bone Tumor Surgery of Forearm. Biomed. J. Sci. Tech. 2018, 10. [CrossRef] open in new tab
  5. Manić, M.; Stamenković, Z.; Mitković, M.; Stojković, M.; Shepherd, D.E.T. Design of 3D Model of Customized Anatomically Adjusted Implants. Facta Univ. Ser. Mech. Eng. 2015, 13, 269-282. open in new tab
  6. Pilliar, R.M. Metallic Biomaterials. In Biomedical Materials; Narayan, R.C., Ed.; Springer Science+Business Media, LLC: Berlin/Heidelberg, Germany, 2009; Volume 2, pp. 41-81. [CrossRef] open in new tab
  7. Wang, D.; Wang, Y.; Wu, S.; Lin, H.; Yang, Y.; Fan, S.; Gu, C.; Wang, J.; Song, C. Customized a Ti6Al4V Bone Plate for Complex Pelvic Fracture by Selective Laser Melting. Materials 2017, 10, 35. [CrossRef] open in new tab
  8. Moiduddin, K.; Mian, S.H.; Umer, U.; Alkhalefah, H. Fabrication and Analysis of a Ti6Al4V Implant for Cranial Restoration. Appl. Sci. 2019, 9, 2513. [CrossRef] open in new tab
  9. Xue, W.; Krishna, B.V.; Bandyopadhyay, A.; Bose, S. Processing and biocompatibility evaluation of laser proceeded porous titanium. Acta Biomater. 2007, 3, 1007-1018. [CrossRef] open in new tab
  10. Sarker, A.; Tran, N.; Rifai, A.; Brandt, M.; Tran, P.A.; Leary, M.; Fox, K.; Williams, R. Rational design of additively manufactured Ti6Al4V implants to control Staphylococcus aureus biofilm formation. Materialia 2019, 5, 100250. [CrossRef] open in new tab
  11. Chu, T.G.; Khouja, N.; Chahine, G.; Kovacevic, R.; Koike, M.; Okabe, T. In vivo Evaluation of a Novel Custom-Made press-Fit Dental Implant Through Electron Beam Melting ® (EBM ® ). Int. J. Dent. Oral Sci. 2016, 3, 358-365.
  12. Minagar, S.; Wang, J.; Bernt, C.C.; Ivanova, E.P.; Wen, C. Cell response of anodized nanotubes on titanium and titanium alloys. J. Biomed. Mater. Res. A 2013, 101A, 2726-2739. [CrossRef] open in new tab
  13. Radtke, A. Photocatalytic Activity of Titania Nanotube Coatings Enriched With Nanohydroxyapatite. Biomed. J. Sci. Tech. Res. 2019, 15. [CrossRef] open in new tab
  14. Li, X.; Gao, P.; Wan, P.; Pei, Y.; Shi, L.; Fan, B.; Shen, C.; Xiao, X.; Yang, K.; Guo, Z. Novel Bio-functional Magnesium Coating on Porous Ti6Al4V Orthopaedic Implants: In vitro and In vivo Study. Sci. Rep. 2017, 7, 40755. [CrossRef] [PubMed] open in new tab
  15. Godoy-Gallardo, M.; Rodríguez-Hernández, A.G.; Delgado, L.M.; Manero, J.M.; Gil, F.J.; Rodríguez, D. Silver deposition on titanium surface by electrochemical anodizing process reduces bacterial adhesion of Streptococcus sanguinis and Lactabacillus salivarius. Clin. Oral Impl. Res. 2015, 26, 1170-1179. [CrossRef] [PubMed] open in new tab
  16. Piszczek, P.; Radtke, A. Silver Nanoparticles Fabricated Using Chemical Vapor Deposition and Atomic Layer Deposition Techniques: Properties, Applications and Perspectives: Review. In Noble and Precious Metals; open in new tab
  17. Seehra, M.S., Bristow, A.D., Eds.; IntechOpen: London, UK, 2018; pp. 187-213. open in new tab
  18. Kasemo, B.; Lausmaa, J. Biomaterial and implant surfaces: A surface science approach. Int. J. Oral Maxillofac. Implant. 1988, 3, 247-259. open in new tab
  19. Takebe, J.; Itoh, S.; Okada, J.; Ishibashi, K. Anodic oxidation and hydrothermal treatment of titanium results in a surface that causes increased attachment and altered cytoskeletal morphology of rat bone marrow stromal cells in vitro. J. Biomed. Mater. Res. 2000, 51, 398-407. [CrossRef] open in new tab
  20. Dzhurinskiy, D. Bioactive antimicrobial coatings for implantable medical devices formed by plasma electrolytic oxidation. Met. Form. 2018, 29, 65-76.
  21. Radtke, A.; Topolski, A.; Jedrzejewski, T.; Kozak, W.; Sadowska, B.; Wieckowska-Szakiel, M.; Piszczek, P. Bioactivity Studies on Titania Coatings and the Estimation of Their Usefulness in the Modification of Implant Surfaces. Nanomaterials 2017, 4, 90. [CrossRef] open in new tab
  22. Radtke, A.; Bal, M.; Jędrzejewski, T. Novel titania nanocoatings produced by the anodic anodization with the use of the cyclically changing potential; their photocatalytic activity and biocompability. Nanomaterials 2018, 8, 712. [CrossRef] open in new tab
  23. Gong, D.; Grimes, C.A.; Varghese, O.K.; Hu, W.; Singh, R.S.; Chen, Z.; Dickey, E.C. Titanium oxide nanotube arrays prepared by anodic oxidation. J. Mater. Res. 2001, 16, 3331-3334. [CrossRef] open in new tab
  24. Macak, J.M.; Tsuchiya, H.; Ghicov, A.; Yasuda, K.; Hahn, R.; Bauer, S.; Schmuki, P. TiO 2 nanotubes: Self-organized electrochemical formation, properties and applications. Curr. Opin. Solid State Mater. Sci. 2007, 11, 3-18. [CrossRef] open in new tab
  25. Lewandowska,Ż.; Piszczek, P.; Radtke, A.; Jędrzejewski, T.; Kozak, W.; Sadowska, B. The Evaluation of the Impact of Titania Nanotube Covers Morphology and Crystal Phase on Their Biological Properties. J. Mater. Sci. Mater. Med. 2015, 26, 163. [CrossRef] [PubMed] open in new tab
  26. Radtke, A.; Topolski, A.; Jędrzejewski, T.; Sadowska, B.; Więckowska-Szakiel, M.; Szubka, M.; Talik, E.; Nielsen, L.P.; Piszczek, P. Studies on the bioactivity and photocatalytic properties of titania nanotube coatings produced with the use of the low potential anodization of Ti6Al4V alloy surface. Nanomaterials 2017, 7, 197. [CrossRef] open in new tab
  27. Radtke, A.; Ehlert, M.; Bartmański, M.; Jędrzejewski, T. The morphology, structure, mechanical properties and biocompatibility of nanotubular titania coatings before and after autoclaving process. J. Clin. Med. 2019, 8, 272. [CrossRef] open in new tab
  28. Radtke, A.; Jędrzejewski, T.; Kozak, W.; Sadowska, B.; Więckowska-Szakiel, M.; Talik, E.; Mäkelä, M.; Leskelä, M.; Piszczek, P. Optimization of the silver clusters PEALD process on the surface of 1-D titania coatings. Nanomaterials 2017, 7, 193. [CrossRef] [PubMed] open in new tab
  29. Piszczek, P.; Lewandowska,Ż.; Radtke, A.; Jędrzejewski, T.; Kozak, W.; Sadowska, B.; Szubka, M.; Talik, E.; Fiori, F. Biocompatibility of Titania Nanotube Coatings Enriched with Silver Nanograins by Chemical Vapor Depositiom. Nanomaterials 2017, 7, 274. [CrossRef] [PubMed] open in new tab
  30. Radtke, A.; Grodzicka, M.; Ehlert, M.; Muzioł, T.; Szkodo, M.; Bartmański, M.; Piszczek, P. Studies on silver ions releasing processes and mechanical properties of surface-modificated titanium alloy implants, International Journal of Molecular Science. Int. J. Mol. Sci. 2018, 19, 3962. [CrossRef] open in new tab
  31. Radtke, A.; Grodzicka, M.; Ehlert, M.; J&#x119, *!!! REPLACE !!!*; drzejewski, T.; Wypij, M.; Goli&#x144, *!!! REPLACE !!!*; ska, P. "To Be Microbiocidal and Not to be Cytotoxic at the Same Time."-Silver Nanoparticles in Their Main Role on the Surface of the Titania Alloy Implant. J. Clin. Med. 2019, 8, 334. [CrossRef] open in new tab
  32. Radtke, A. 1D Titania Nanoarchitecture as Bioactive and Photoactive Coatingas for Modern Implants: A Review. In Application of Titanium Dioxide; Janus, M., Ed.; InTech: Croatia, 2017; pp. 73-102. open in new tab
  33. Sonntag, R.; Reinders, J.; Gibmeier, J.; Kretzer, J.P. Fatigue Performance of Medical Ti6Al4V Alloy after Mechanical Surface Treatments. PLoS ONE 2015, 10, e0121963. [CrossRef] open in new tab
  34. Yuan, Y.; Lee, T.R. Chapter 1 Contact Angle and Wetting Properties. In Surface Science Techniques, Springer Series in Surface Sciences; Bracco, G., Holst, B., Eds.; Springer: Berlin/Heidelberg, Germany, 2013; pp. 3-34. [CrossRef] open in new tab
  35. Flückiger-Isler, S.; Kamber, M. Direct comparison of the Ames microplate format (MPF) test in liquid medium with the standard Ames pre-incubation assay on agar plates by use of equivocal to weakly positive test compounds. Mutat. Res. Toxicol. Environ. Mutagen 2012, 747, 36-45. [CrossRef] open in new tab
  36. Leyland, A.; Matthews, A. Design criteria for wear-resistant nanostructured and glassy-metal coatings. Surf. Coat. Technol. 2004, 177-178, 317-324. [CrossRef] open in new tab
  37. Oliver, W.C.; Pharr, G.M. An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments. J. Mater. Res. 1992, 7, 1564-1583. [CrossRef] open in new tab
  38. Atuchin, V.V.; Kesler, V.G.; Pervukhina, N.V.; Zhang, Z. Ti 2p and O 1s core levels and chemical bonding in titanium-bearing oxides. J. Electron Spectrosc. Relat. Phenom. 2006, 152, 18-24. [CrossRef] open in new tab
  39. Chinh, V.D.; Broggi, A.; Di Palma, L.; Scarsella, M.; Sperenza, G.; Vilardi, G.; Thang, P.N. XPS Spectra Analysis of Ti 2+ , Ti 3+ Ions and Dye Photodegradation Evaluation of Titania-Silica Mixed Oxide Nanoparticles. J. Phys. D Appl. Phys. 2017, 10. [CrossRef] open in new tab
  40. Wen, H.; Dan, M.; Yang, Y.; Lyu, J.; Shao, A.; Cheng, X.; Chen, L.; Xu, L. Acute toxicity and genotoxicity of silver nanoparticle in rats. PLoS ONE 2017, 12, e0185554. [CrossRef] [PubMed] open in new tab
  41. Li, Y.; Qin, T.; Ingle, T.; Yan, J.; He, W.; Yin, J.J.; Chen, T. Differential genotoxicity mechanisms of silver nanoparticles and silver ions. Arch Toxicol. 2017, 91, 509-519. [CrossRef] [PubMed] open in new tab
  42. Jemat, A.; Ghazali, M.J.; Razali, M.; Otsuka, Y.; Rajabi, A. Effects of TiO 2 on microstructural, mechanical properties and in-vitro bioactivity of plasma sprayed yttria stabilised zirconia coatings for dental application. Ceram. Int. 2017, 44, 4271-4281. [CrossRef] open in new tab
  43. Rayón, E.; Bonache, V.; Salvador, M.D.; Bannier, E.; Sánchez, E.; Denoirjean, A.; Ageorges, H. Nanoindentation study of the mechanical and damage behaviour of suspension plasma sprayed TiO 2 coatings. Surf. Coat. Technol. 2012, 206, 2655-2660. [CrossRef] open in new tab
  44. Wysocki, B.; Maj, P.; Sitek, R.; Buhagiar, J.; Kurzydłowski, K.J.;Święszkowski, W. Laser and Electron Beam Additive Manufacturing Methods of Fabricating Titanium Bone Implants. Appl. Sci. 2017, 7, 657. [CrossRef] open in new tab
  45. Hiromoto, S.; Hanawa, T.; Asami, K. Composition of surface oxide film of titanium with culturing Marine fibroblast L929. Biomaterials 2004, 25, 979-986. [CrossRef] open in new tab
  46. Brammer, K.S.; Oh, S.; Cobb, C.J.; Bjursten, L.M.; van der Heyde, H.; Jin, S. Improved bone-forming functionality on diameter-controlled TiO 2 nanotube surface. Acta Biomater. 2009, 5, 3215-3223. [CrossRef] [PubMed] open in new tab
  47. Park, J.; Bauer, S.; von der Mark, K.; Schmuki, P. Nanosize and vitality: TiO 2 nanotube diameter directs cell fate. Nano Lett. 2007, 7, 1686-1691. [CrossRef] [PubMed] open in new tab
  48. Park, J.; Bauer, S.; Schlegel, K.A.; Neukam, F.W.; von der Mark, K.; Schmuki, P. TiO 2 nanotube surfaces: 15 nm-an optimal length scale of surface topography for cell adhesion and differentiation. Small 2009, 5, 666-671. [CrossRef] open in new tab
  49. Albers, C.E.; Hofstetter, W.; Siebenrock, K.A.; Landmann, R.; Klenke, F.M. In vitro cytotoxicity of silver nanoparticles on osteoblasts and osteoclasts at antibacterial concentrations. Nanotoxicology 2013, 7, 30-36. [CrossRef] [PubMed] open in new tab
  50. Castiglioni, S.; Cazzania, A.; Locatelli, L.; Maier, J.A.M. Silver Nanoparticles in Orthopedic Applications: New Insights on Their Effects on Osteogenic Cells. Nanomaterials (Basel) 2017, 7, 124. [CrossRef] [PubMed] open in new tab
  51. Shivaram, A.; Bose, S.; Bandyopadhyay, A. Mechanical degradation of TiO 2 nanotubes with and without nanoparticulate silver coating. J. Mech. Behav. Biomed. Mater. 2016, 59, 508-518. [CrossRef] [PubMed] open in new tab
  52. Zhao, L.; Wang, H.; Huo, K.; Cui, L.; Zhang, W.; Ni, H.; Zhang, Y.; Wu, Z.; Chu, P.K. Antibacterial nano-structured titania coating incorporated with silver nanoparticles. Biomaterials 2011, 32, 5706-5716. [CrossRef] open in new tab
  53. Esfandiari, N.; Simchi, A.; Bagheri, R. Size tuning of Ag-decorated TiO 2 nanotube arrays for improved bactericidal capacity of orthopedic implants. J. Biomed. Mater. Res. A. 2014, 102, 2625-2635. [CrossRef] open in new tab
  54. Fenton, M.J.; Golenbock, D.T. LPS-binding proteins and receptors. J. Leuk. Biol. 1998, 64, 25-32. [CrossRef] open in new tab
  55. Netea, M.G.; Kullberg, B.J.; van der Meer, J.W. Circulating cytokines as mediators of fever. Clin. Infect. Dis. 2000, 31, S178-S184:. [CrossRef] open in new tab
  56. Neacsu, P.; Mazare, A.; Cimpean, A.; Park, J.; Costache, M.; Schmuki, P.; Demetrescu, I. Reduced inflammatory activity of RAW 264.7 macrophages on titania nanotube modified Ti surface. Int. J. Biochem. Cell. Biol. 2014, 55, 187-195. [CrossRef] [PubMed] open in new tab
  57. Furuhashi, A.; Ayukawa, Y.; Atsuta, I.; Okawachi, H.; Koyano, K. The difference of fibroblast behavior on titanium substrata with different surface characteristics. Odontology 2012, 100, 199-205. [CrossRef] [PubMed] open in new tab
  58. Tan, K.S.; Qian, L.; Rosado, R.; Flood, P.M.; Cooper, L.F. The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production. Biomaterials 2006, 27, 5170-5177. [CrossRef] [PubMed] open in new tab
  59. Dinarello, C.A. Proinflammatory cytokines. Chest 2000, 118, 503-508. [CrossRef] open in new tab
  60. Radi, R. Nitric oxide, oxidants, and protein tyrosine nitration. Proc. Natl. Acad. Sci. USA 2004, 101, 4003-4008. [CrossRef] open in new tab
  61. Mosser, D.M.; Zhang, X. Interleukin-10: new perspectives on an old cytokine. Immunol. Rev. 2008, 226, 205-218. [CrossRef] open in new tab
  62. Ullah Khan, S.; Saleh, T.A.; Wahab, A.; Khan, M.H.U.; Khan, D.; Ullah Khan, W.; Rahim, A.; Kamal, S.; Fahad, S. Nanosilver: new ageless and versatile biomedical therapeutic scaffold. Int. J. Nanomedicine. 2018, 13, 733-762. [CrossRef] open in new tab
  63. Goodman, S.B.; Ma, T. Cellular chemotaxis induced by wear particles from joint replacements. Biomaterials 2010, 31, 5045-5050. [CrossRef] open in new tab
  64. Swift, L.H.; Golsteyn, R.M. Genotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cells. Int. J. Mol. Sci. 2014, 15, 3403-3431. [CrossRef] open in new tab
  65. Velasco-Ortega, E.; Jos, A.; Cameán, A.M.; Pato-Mourelo, J.; Segura-Egea, J.J. In vitro evaluation of cytotoxicity and genotoxicity of a commercial titanium alloy for dental implantology. Mutation Res. Genetic Toxicol. Environ. Mutag. 2010, 702, 17-22. [CrossRef] open in new tab
  66. Ghosh, M.J.M.; Sinha, S.; Chakraborty, A.; Mallick, S.K.; Bandyopadhyay, M.; Mukherjee, A. In vitro and in vivo genotoxicity of silver nanoparticles. Mut. Res./Genet. Toxicol. Environ. Mutagen. 2012, 749, 60-69. [CrossRef] open in new tab
  67. Li, Y.; Bhalli, J.A.; Ding, W.; Yan, J.; Pearce, M.G.; Sadiq, R.; Cunningham, C.K.; Jones, M.Y.; Monroe, W.A.; Howard, P.C.; et al. Cytotoxicity and genotoxicity assessment of silver nanoparticles in mouse. Nanotoxicology 2014, 8, 36-45. [CrossRef] open in new tab
  68. Lebedová, J.; Hedberg, Y.S.; Odnevall Wallinder, I.; Karlsson, H.L. Size-dependent genotoxicity of silver, gold and platinum nanoparticles studied using the mini-gel comet assay and micronucleus scoring with flow cytometry. Mutagenesis 2018, 33, 77-85. [CrossRef] [PubMed] open in new tab
  69. Burmølle, M.; Thomsen, T.R.; Fazli, M.; Dige, I.; Christensen, L.; Homøe, P.; Tvede, M.; Nyvad, B.; Tolker-Nielsen, T.; Givskov, M.; et al. Biofilms in chronic infections -a matter of opportunity -monospecies biofilms in multispecies infections. FEMS Immunol. Med. Microbiol. 2010, 59, 324-336. [CrossRef] open in new tab
  70. Høiby, N.; Bjarnsholt, T.; Givskov, M.; Molin, S.; Ciofu, O. Antibiotic resistance of bacterial biofilms. Intern. J. Antim. Agents 2010, 35, 322-332. [CrossRef] open in new tab
  71. Leid, J.G.; Cope, E. Population level virulence in polymicrobial communities associated with chronic disease. Front. Biol. 2011, 6, 435-445. [CrossRef] open in new tab
  72. Mottola, C.; Matias, C.S.; Mendes, J.J.; Melo-Cristino, J.; Tavares, L.; Cavaco-Silva, P.; Oliveira, M. Susceptibility patterns of Staphylococcus aureus biofilms in diabetic foot infections. BMC Microbiol. 2016, 16, 1-9. [CrossRef] open in new tab
  73. Jin, J.; Zhang, L.; Shi, M.; Zhang, Y.; Wang, Q. Ti-GO-Ag nanocomposite: the effect of content level on the antimicrobial activity and cytotoxicity. Int. J. Nanomed. 2017, 12, 4209-4224. [CrossRef] open in new tab
  74. Lan, M.-Y.; Liu, C.-P.; Huang, H.-H.; Lee, S.-W. Both enhanced biocompatibility and antibacterial activity in Ag-decorated TiO2 nanotubes. PLoS ONE 2013, 8, 1-8. [CrossRef] open in new tab
  75. Liu, R.; Memarzadeh, K.; Chang, B.; Zhang, Y.; Ma, Z.; Allaker, R.P.; Ren, L.; Yang, K. Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against. Strept. Mutans Porphyrom. Gingival. Scientific Rep. 2016, 6, 29985. [CrossRef] open in new tab
  76. Besinis, A.; Hadi, S.D.; Le, H.R.; Tredwin, C.; Handy, R.D. Antibacterial activity and biofilm inhibition by surface modified titanium alloy medical implants following application of silver, titanium dioxide and hydroxyapatite nanocoatings. Nanotoxicology 2017, 11, 327-338. [CrossRef] [PubMed] open in new tab
  77. Dudek, K.; Dulski, M.; Goryczka, T.; Gerle, A. Structural changes of hydroxyapatite coating electrophoretically deposited on NiTi shape memory alloy. Ceram. Int. 2018, 44, 11292-11300. [CrossRef] open in new tab
  78. He, J.; Zhou, W.; Zhou, X.; Zhong, X.; Zhang, X.; Wan, P.; Zhu, B.; Chen, W. The anatase phase of nanotopography titania plays an important role on osteoblast cell morphology and proliferation. J. Mater. Sci. Mater. Med. 2008, 19, 3465-3472. [CrossRef] [PubMed] open in new tab
  79. Ferreira Soares, P.B.; Moura, C.C.G.; Claudino, M.; Carvalho, V.F.; Rocha, F.S.; Zanetta-Barbosa, D. Influence of implant surfaces on osseointegration: A histomorphometric and implant stability study in rabbits. Braz. Dent. J. 2015, 26, 451-457. [CrossRef] [PubMed] open in new tab
  80. Wang, X.; Wang, G.; Liang, J.; Cheng, J.; Ma, W.; Zhao, Y. Staphylococcus aureus adhesion to different implant surface coatings: An in vitro study. Surf. Coatings Technol. 2009, 203, 3454-3458. [CrossRef] open in new tab
  81. Bahadur, J.; Agrawal, S.; Panwar, V.; Parveen, A.; Pal, K. Antibacterial properties of silver doped TiO 2 nanoparticles synthesized via sol-gel technique. Macromol. Res. 2016, 24, 488-493. [CrossRef] open in new tab
  82. Godoy-Gallardo, M.; Manzanares-Céspedes, M.C.; Sevilla, P.; Nart, J.; Manzanares, N.; Manero, J.M.; Gil, F.J.; Boyd, S.K.; Rodríguez, D. Evaluation of bone loss in antibacterial coated dental implants: An experimental study in dogs. Mater. Sci. Eng. C Mater. Biol. Appl. 2016, 1, 538-545. [CrossRef] open in new tab
  83. Wang, W.K.; Wen, H.C.; Cheng, C.H.; Hung, C.H.; Chou, W.C.; Yau, W.H.; Yang, P.F.; Lai, Y.S. Nanotribological properties of ALD-processed bilayer TiO 2 /ZnO films. Microelectron. Reliab. 2014, 54, 2754-2759. [CrossRef] open in new tab
  84. Bartmanski, M.; Zielinski, A.; Majkowska-Marzec, B.; Strugala, G. Effects of solution composition and electrophoretic deposition voltage on various properties of nanohydroxyapatite coatings on the Ti13Zr13Nb alloy. Ceram. Int. 2018, 19236-19246. [CrossRef] open in new tab
  85. Sumner, D.R.; Galante, J.O. Determinants of stress shielding: Design versus materials versus interface. Clin. Orthop. Relat. Res. 1992, 274, 202-212. [CrossRef] open in new tab
  86. Ridzwan, M.I.Z.; Shuib, S.; Hassan, A.Y.; Shokri, A.A.; Mohammad Ibrahim, M.N. Problem of stress shielding and improvement to the hip implant designs: A review. J. Med. Sci. 2007, 7, 460-467. [CrossRef] open in new tab
  87. Huiskes, R.; Weinans, H.; Van Rietbergen, B. The relationship between stress shielding and bone resorption around total hip stems and the effects of flexible materials. Clin. Orthop. Relat. Res. 1992, 124-134. [CrossRef] open in new tab
  88. Asgharzadeh Shirazi, H.; Ayatollahi, M.R.; Asnafi, A. To reduce the maximum stress and the stress shielding effect around a dental implant-bone interface using radial functionally graded biomaterials. Comput. Methods Biomech. Biomed. Engin. 2017, 20, 750-759. [CrossRef] [PubMed] open in new tab
  89. Noyama, Y.; Miura, T.; Ishimoto, T.; Itaya, T.; Niinomi, M.; Nakano, T. Bone loss and reduced bone quality of the human femur after total hip arthroplasty under stress-shielding effects by titanium-based implant. Mater. Trans. 2012, 53, 565-570. [CrossRef] open in new tab
  90. Drevet, R.; Ben Jaber, N.; Fauré, J.; Tara, A.; Ben Cheikh Larbi, A.; Benhayoune, H. Electrophoretic deposition (EPD) of nano-hydroxyapatite coatings with improved mechanical properties on prosthetic Ti6Al4V substrates. Surf. Coatings Technol. 2015, 301, 94-99. [CrossRef] open in new tab
  91. Charles, A.H. Handbook of Ceramics, Glasses, and Diamonds, Charles, A.H., Ed.; The McGraw-Hill Companies Inc.: New York, NY, USA, 2001. [CrossRef] open in new tab
  92. Manoj Kumar, R.; Kuntal, K.K.; Singh, S.; Gupta, P.; Bhushan, B.; Gopinath, P.; Lahiri, D. Electrophoretic deposition of hydroxyapatite coating on Mg-3Zn alloy for orthopaedic application. Surf. Coatings Technol. 2016, 287, 82-92. [CrossRef] open in new tab
  93. Bartmański, M.; Cieślik, B.; Głodowska, J.; Kalka, P. Electrophoretic deposition (EPD) of nanohydroxyapatite -nanosilver coatings on Ti13Zr13Nb alloy. Ceram. Int. 2017, 43, 11820-11829. [CrossRef] open in new tab
  94. Chernozem, R.V.; Surmeneva, M.A.; Krause, B.; Baumbach, T.; Ignatov, V.P.; Tyurin, A.I.; Loza, K.; Epple, M.; Surmenev, R.A. Hybrid biocomposites based on titania nanotubes and a hydroxyapatite coating deposited by RF-magnetron sputtering: Surface topography, structure, and mechanical properties. Appl. Surf. Sci. 2017, 426, 229-237. [CrossRef] open in new tab
  95. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). open in new tab
Verified by:
Gdańsk University of Technology

seen 18 times

Recommended for you

Meta Tags