Comprehensive Evaluation of the Biological Properties of Surface-Modified Titanium Alloy Implants - Publication - MOST Wiedzy

Search

Comprehensive Evaluation of the Biological Properties of Surface-Modified Titanium Alloy Implants

Abstract

An increasing interest in the fabrication of implants made of titanium and its alloys results from their capacity to be integrated into the bone system. This integration is facilitated by different modifications of the implant surface. Here, we assessed the bioactivity of amorphous titania nanoporous and nanotubular coatings (TNTs), produced by electrochemical oxidation of Ti6Al4V orthopedic implants’ surface. The chemical composition and microstructure of TNT layers was analyzed by X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). To increase their antimicrobial activity, TNT coatings were enriched with silver nanoparticles (AgNPs) with the chemical vapor deposition (CVD) method and tested against various bacterial and fungal strains for their ability to form a biofilm. The biointegrity and anti-inflammatory properties of these layers were assessed with the use of fibroblast, osteoblast, and macrophage cell lines. To assess and exclude potential genotoxicity issues of the fabricated systems, a mutation reversal test was performed (Ames Assay MPF, OECD TG 471), showing that none of the TNT coatings released mutagenic substances in long-term incubation experiments. The thorough analysis performed in this study indicates that the TNT5 and TNT5/AgNPs coatings (TNT5—the layer obtained upon applying a 5 V potential) present the most suitable physicochemical and biological properties for their potential use in the fabrication of implants for orthopedics. For this reason, their mechanical properties were measured to obtain full system characteristics.

Citations

  • 1

    CrossRef

  • 0

    Web of Science

  • 0

    Scopus

Authors

Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
Journal of Clinical Medicine no. 9, pages 1 - 29,
ISSN: 2077-0383
Language:
English
Publication year:
2020
Bibliographic description:
Piszczek P., Radtke A., Ehlert M., Jędrzejewski T., Sznarkowska A., Sadowska B., Bartmański M., Erdogan Y., Ercan B., Jędrzejczyk W.: Comprehensive Evaluation of the Biological Properties of Surface-Modified Titanium Alloy Implants// Journal of Clinical Medicine -Vol. 9,iss. 2 (2020), s.1-29
DOI:
Digital Object Identifier (open in new tab) 10.3390/jcm9020342
Verified by:
Gdańsk University of Technology

seen 0 times

Recommended for you

Meta Tags