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Convenient synthesis of 3-phosphono-β-lactams through the cyclization ofN-alkenyl-phosphonoacetamides
Abstract
Oxidative cyclization through the treatment by the transition metals is convenientsynthetic tool with a great number of applications. In the most cases the result is the formationof C-C bond between generated radical and unsaturated part of the same or another molecule.As it was presented by Trogolo it is also suitable way to obtain 4-membered heterocyclicβ-lactamic ring[1]. In this communicate we want to present new application of mentionedabove method. It is possible to obtain undescribed so far 3-phosphono-β-lactams through theradical cyclization. N-alkenyl-phosphonoacetamides in presence of manganese(III) acetategives β-lactam ring substituted with phosphono group in the third position. In the preliminarystudies we obtained desired products. However, this method requires further work, from theone side to increase yields and from the other side to check substrate spectrum that reacts inthe same manner.The prepared compounds could have interesting activities in order to structure similarity withβ-lactam antibiotics.
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- Category:
- Monographic publication
- Type:
- rozdział, artykuł w książce - dziele zbiorowym /podręczniku w języku o zasięgu międzynarodowym
- Title of issue:
- ''Advances in Chemical and Mechanical Engineering''. Vol. II/II strony 157 - 158
- Language:
- English
- Publication year:
- 2012
- Bibliographic description:
- Punda P.: Convenient synthesis of 3-phosphono-β-lactams through the cyclization ofN-alkenyl-phosphonoacetamides// ''Advances in Chemical and Mechanical Engineering''. Vol. II/II/ ed. eds. C. Fijało, P. Fijało. - Gdansk University of Technology. Gdańsk: GUT, 2012, s.157-158
- Verified by:
- Gdańsk University of Technology
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