Copper(II) complexes with substituted imidazole and chlorido ligands: X-ray, UV-Vis, magnetic and EPR studies and chemotherapeutic potential

Sylwia Godlewska; Julia Jezierska; Katarzyna Kazimierczuk; Ewa Augustin; Anna Dołęga

Copper(II) complexes with substituted imidazole and chlorido ligands: X-ray, UV-Vis, magnetic and EPR studies and chemotherapeutic potential

Abstract

Crystal structures, UV-Vis and EPR spectra and magnetic properties of four copper(II) complexes with chloride anions and 4-methylimidazole, 2-ethylimidazole, 2-isopropylimidazole or 2-ethyl-4-methylimidazole are described. In the solid state three of the complexes are mononuclear and one complex with 2-ethylimidazole is binuclear with bridging chlorido ions. UV-Vis spectra of the methanolic solutions of the complexes show LMCT bands characteristic for the presence of Cu-N(imidazole) and Cu-Cl coordination bonds. The visible part of the UV-Vis spectrum indicates that in solution the complexes adopt similar geometries. Powdered compounds exhibit anisotropic X-band EPR spectra: axial for complexes with 4-methylimidazole and 2-ethyl-4-methylimidazole and rhombic for the complex with 2-isopropylimidazole. Spin-spin interaction between Cu(II) ions in the binuclear complex with 2-ethylimidazole has mainly dipole-dipole character. In frozen methanol solutions the EPR spectra of all studied complexes prove similar axial symmetry of the coordination polyhedra. The results of cytotoxicity tests of the complexes against U937 lymphoma show comparable, moderate antineoplastic activity of the tested compounds.

Authors (5)

Sylwia Godlewska mgr inż.
Julia Jezierska
- Uniwersytet Wrocławski Wydział Chemii
Katarzyna Kazimierczuk dr hab.
Ewa Augustin dr hab.
Anna Dołęga prof. dr hab. inż.

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Category:: Articles
Type:: artykuł w czasopiśmie wyróżnionym w JCR
Published in:: POLYHEDRON no. 65, pages 288 - 297,
ISSN: 0277-5387
Language:: English
Publication year:: 2013
Bibliographic description:: Godlewska S., Jezierska J., Kazimierczuk K., Augustin E., Dołęga A.: Copper(II) complexes with substituted imidazole and chlorido ligands: X-ray, UV-Vis, magnetic and EPR studies and chemotherapeutic potential// POLYHEDRON. -Vol. 65, (2013), s.288-297
Verified by:: Gdańsk University of Technology