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Cu-HKUST-1 and Hydroxyapatite–The Interface of Two Worlds toward the Design of Functional Materials Dedicated to Bone Tissue Regeneration
Abstract
A novel composite based on biocompatible hydroxyapatite (HA) nanoparticles and Cu-HKUST-1 (Cu-HKUST-1@HA) has been prepared following a layer-by-layer strategy. Cu-HKUST-1 was carefully selected from a group of four Cu-based metal−organic frameworks as the material with the most promising antimicrobial activity. The formation of a colloidal Cu- HKUST-1 layer on HA nanoparticles was confirmed by various techniques, e.g., infrared spectroscopy, powder X-ray diffraction, N2 sorption, transmission electron microscopy imaging, electron paramagnetic resonance, and X-ray absorption spectroscopy. Importantly, such a Cu-HKUST-1 layer significantly improved the nanomechanical properties of the composite, with Young’s modulus equal to that of human cortical bone (13.76 GPa). At the same time, Cu-HKUST-1@HA has maintained the negative zeta potential (−16.3 mV in pH 7.4) and revealed biocompatibility toward human dermal fibroblasts up to a concentration of 1000 μg/mL, without inducing ex vivo hemolysis. Chemical stability studies of the composite over 21 days in a buffer-simulated physiological fluid allowed a detailed understanding of the transformations that the Cu-HKUST-1@HA undergoes over time. Finally, it has been confirmed that the Cu-HKUST-1 layer provides antibacterial properties to HA, and the synergism reached in this way makes it promising for bone tissue regeneration.
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Authors (9)
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Marzena Fandzloch
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Weronika Bodylska
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Joanna Trzcińska-Wencel
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Patrycja Golińska
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Katarzyna Roszek dr hab.
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Joanna Wiśniewska
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Agnieszka Lewińska
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Anna Jaromin
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1021/acsbiomaterials.3c00594
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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ACS Biomaterials Science & Engineering
no. 9,
pages 4646 - 4653,
ISSN: 2373-9878 - Language:
- English
- Publication year:
- 2023
- Bibliographic description:
- Fandzloch M., Bodylska W., Trzcińska-Wencel J., Golińska P., Roszek K., Wiśniewska J., Bartmański M., Lewińska A., Jaromin A.: Cu-HKUST-1 and Hydroxyapatite–The Interface of Two Worlds toward the Design of Functional Materials Dedicated to Bone Tissue Regeneration// ACS Biomaterials Science & Engineering -,iss. 8 (2023), s.4646-4653
- DOI:
- Digital Object Identifier (open in new tab) 10.1021/acsbiomaterials.3c00594
- Sources of funding:
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- Free publication
- Verified by:
- Gdańsk University of Technology
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