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Abstract
We studied the presence of triazole resistance of 121 Aspergillus fumigatus clinical isolates collected in two Polish cities, Warsaw and Wrocław, to determine if resistance is emerging in our country. We identified five itraconazole resistant isolates (4.13%) carrying the TR34/L98H alteration in Cyp51A gene, four of which were cross-resistant to posaconazole and one to voriconazole. One isolate was intermediate susceptible to itraconazole and harbored no Cyp51A alterations. The study confirms the presence of azole resistant A. fumigatus strains in Poland at a level that is comparative to other European countries.
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Authors (11)
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Urszula Nawrot
- Uniwersytet Medyczny we Wrocławiu, Wydział Farmaceutyczny Zakład Mikrobiologii Farmaceutycznej z Oddziałem Analityki Medycznej
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Maiken Cavling Arendrup
- Rigshospitalet, Copenhagen University, Copenhagen Department of Clinical Microbiology
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Katarzyna Włodarczyk
- Uniwersytet Medyczny we Wrocławu, Wydział Farmaceutyczny Zakład Mikrobiologii Farmaceutycznej z Oddziałem Analityki Medycznej
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Beata Sulik-tyszka
- Central Clinical Hospital in Warsaw, Medical University of Warsaw Department of Microbiology
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Marta Wróblewska
- Medical University of Warsaw Department of Dental Microbiology
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Marek Ussowicz
- Oncology and Hematology, Wroclaw Medical University Department of Pediatric Bone Marrow Transplantation
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Przemysław Zdziarski
- Institute of Immunology and Experimental Therapy Department of Immunology and Infectious Diseases,
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Katarzyna Niewińska
- Paediatric Intensive Care Unit Wroclaw Medical University, Department of Anesthesiology and Intensive Therapy
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
MEDICAL MYCOLOGY
no. 56,
edition 1,
pages 1 - 4,
ISSN: 1369-3786 - Language:
- English
- Publication year:
- 2018
- Bibliographic description:
- Nawrot U., Kurzyk E., Arendrup M., Mroczyńska M., Włodarczyk K., Sulik-Tyszka B., Wróblewska M., Ussowicz M., Zdziarski P., Niewińska K., Brillowska-Dąbrowska A.: Detection of Polish clinical Aspergillus fumigatus isolates resistant to triazoles// MEDICAL MYCOLOGY. -Vol. 56, iss. 1 (2018), s.1-4
- DOI:
- Digital Object Identifier (open in new tab) 10.1093/mmy/myx012
- Verified by:
- Gdańsk University of Technology
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