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Abstract
Pharmaceutical products can be contaminated by residues of solvents, reagents (used for the synthesis) or degradation products. Impurities in drug may pose a risk to human health and life, therefore analysis and identification of impurities in pharmaceutical products is veryimportant and inevitable.High performance liquid chromatography coupled with mass spectrometry (MS) is very useful technique for identification impurities in pharmaceuticals. Moreover it is ideally suited to the analysis of known or suspected compounds. However, MS does not give detailed structural information (for example, generally it is not possible to distinguish between isomers). More structural information can be obtained using LC-NMR, therefore using of this two techniquessimultaneously can give complementary structural information for unknown polar and nonvolatile compounds.
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- Category:
- Monographic publication
- Type:
- rozdział, artykuł w książce - dziele zbiorowym /podręczniku w języku o zasięgu międzynarodowym
- Title of issue:
- ''Advances in Chemical and Mechanical Engineering''. -Vol. II/II strony 301 - 306
- Language:
- English
- Publication year:
- 2012
- Bibliographic description:
- Wilczewska K.: Determination of impurities in pharmaceutical products using LC-MS// ''Advances in Chemical and Mechanical Engineering''. -Vol. II/II/ ed. ed. C. Fijało. - Gdansk University of Technology, Faculty of Mechanical Engineering, Chemical Faculty. Gdańsk: GUT, 2012, s.301-306
- Verified by:
- Gdańsk University of Technology
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