Development of thin film SPME sorbents based on deep eutectic solvents and their application for isolation and preconcentration of endocrine-disrupting compounds leaching from diapers to urine

Aneta Chabowska; Justyna Werner; Agnieszka Zgoła-Grześkowiak; Julia Płatkiewicz; Robert Frankowski; Justyna Płotka-Wasylka

doi:10.1016/j.microc.2024.110023

Development of thin film SPME sorbents based on deep eutectic solvents and their application for isolation and preconcentration of endocrine-disrupting compounds leaching from diapers to urine

Abstract

In this study, the thin film solid phase microextraction (TF-SPME) based on a novel sorbent composed of deep eutectic solvent (DES) is proposed. Among several synthesized sorbents the most efficient was DES containing trihexyl(tetradecyl)phosphonium chloride and docosanol mixed with polydimethylsiloxane (PDMS) in a molar ratio 1:3:0.25 to achieve a more stable structure. The proposed sorbent was applied on a fiberglass mesh and used as a TF-SPME sorbent for the determination of fifteen endocrine-disrupting compounds (EDCs): methylparaben (MeP), ethylparaben (EtP), propylparaben (PrP), butylparaben (BuP), benzylparaben (BzP), bisphenol A (BPA), bisphenol S (BPS), bisphenol F (BPF), bisphenol AF (BPAF), bisphenol E (BPE), bisphenol B (BPB), triclosan (TCS), triclocarban (TCC), butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) leaching from diapers to synthetic urine. A central composite design methodology was used to optimize extraction from urine and four factors were tested, such as mass of DES/PDMS, extraction time, desorption time, and volume of triethylamine (additive to the desorbing solvent). The developed methodology was characterized by good metrological parameters (limit of detection (LOD): 0.01–1.15 ng mL 1, precision: 2.5–10.3 %). The method was linear in the range of 0.1 ng mL 1 to 100 ng mL 1 with a satisfactory coefficient of determination. After preconcentration by TF-SPME, EDCs were determined by LC-MS/MS. The main EDCs found in diapers were BPA, BPS, MeP, EtP, and PrP.

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Authors (6)

Aneta Chabowska
Justyna Werner
- Politechnika Poznańska
Agnieszka Zgoła-Grześkowiak
- Politechnika Poznańska
Julia Płatkiewicz
- Politechnika Poznańska
Robert Frankowski
- Politechnika Poznańska
Justyna Płotka-Wasylka dr hab. inż.

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Articles

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artykuły w czasopismach

Published in:

MICROCHEMICAL JOURNAL no. 199,
ISSN: 0026-265X

Language:

English

Publication year:

2024

Bibliographic description:

Chabowska A., Werner J., Zgoła-Grześkowiak A., Płatkiewicz J., Frankowski R., Płotka-Wasylka J.: Development of thin film SPME sorbents based on deep eutectic solvents and their application for isolation and preconcentration of endocrine-disrupting compounds leaching from diapers to urine// MICROCHEMICAL JOURNAL -Vol. 199, (2024), s.110023-

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