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Dissecting gamma frequency activities during human memory processing

Abstract

Gamma frequency activity (30-150 Hz) is induced in cognitive tasks and is thought to reflect underlying neural processes. Gamma frequency activity can be recorded directly from the human brain using intracranial electrodes implanted in patients undergoing treatment for drug-resistant epilepsy. Previous studies have independently explored narrowband oscillations in the local field potential and broadband power increases. It is not clear, however, which processes contribute to human brain gamma frequency activity, or their dynamics and roles during memory processing. Here a large dataset of intracranial recordings obtained during encoding of words from 101 patients was used to detect, characterize and compare induced gamma frequency activity events. Individual bursts of gamma frequency activity were isolated in the time-frequency domain to determine their spectral features, including peak frequency, amplitude, frequency span, and duration. We found two distinct types of gamma frequency activity events that showed either narrowband or broadband frequency spans revealing characteristic spectral properties. Narrowband events, the predominant type, were induced by word presentations following an initial induction of broadband events, which were temporally separated and selectively correlated with evoked response potentials, suggesting that they reflect different neural activities and play different roles during memory encoding. The two gamma frequency activity types were differentially modulated during encoding of subsequently recalled and forgotten words. In conclusion, we found evidence for two distinct activity types induced in the gamma frequency range during cognitive processing. Separating these two gamma frequency activity components contributes to the current understanding of electrophysiological biomarkers, and may prove useful for emerging neurotechnologies targeting, mapping and modulating distinct neurophysiological processes in normal and epileptogenic brain.

Citations

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Authors (16)

  • Photo of dr Michał Tomasz Kucewicz

    Michał Tomasz Kucewicz dr

    • Mayo Clinic Departament of Neurology
  • Photo of  Brent M. Berry

    Brent M. Berry

    • Mayo Clinic Departament of Neurology
  • Photo of  Vaclav Kremen

    Vaclav Kremen

    • Mayo Clinic Departament of Neurology
  • Photo of  Benjamin H. Brinkmann

    Benjamin H. Brinkmann

    • Mayo Clinic Departament of Neurology
  • Photo of  Michael R. Sperling

    Michael R. Sperling

    • Thomas Jefferson of University Hospital Departament of Neurology
  • Photo of  Barbara C. Jobst

    Barbara C. Jobst

    • Dartmouth-Hitchcock Medicinal Center Departament of Neurology
  • Photo of  Robert E. Gross

    Robert E. Gross

    • Emory University Departament of Neurosurgery
  • Photo of  Bradley Lega

    Bradley Lega

    • University of Texas Southwestern Medicinal Center Departament of Neurosurgery
  • Photo of  Sameer A. Sheth

    Sameer A. Sheth

    • Columbia University Departament of Neurology
  • Photo of  Joel M. Stein

    Joel M. Stein

    • Universyty of Pannsylvania Hospital Departament of Radiology
  • Photo of  Sandhitsu R. Das

    Sandhitsu R. Das

    • Mayo Clinic Departament of Neurology
  • Photo of  Richard Gorniak

    Richard Gorniak

    • Thomas Jefferson of University Hospital Departament of Radiology
  • Photo of  S. Matthew Stead

    S. Matthew Stead

    • Mayo Clinic Departament of Neurology
  • Photo of  Daniel S. Rizzuto

    Daniel S. Rizzuto

    • Universyty of Pannsylvania Departament of Psychology
  • Photo of  Michael J. Kahana

    Michael J. Kahana

    • Universyty of Pannsylvania Departament of Psychology
  • Photo of  Gregory A. Worrell

    Gregory A. Worrell

    • Mayo Clinic Departament of Neurology

Details

Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
Brain: A Journal of Neurology no. 140, pages 1337 - 1350,
ISSN: 0006-8950
Language:
English
Publication year:
2017
Bibliographic description:
Kucewicz M., Berry B., Kremen V., Brinkmann B., Sperling M., Jobst B., Gross R., Lega B., Sheth S., Stein J., Das S., Gorniak R., Stead S., Rizzuto D., Kahana M., Worrell G.: Dissecting gamma frequency activities during human memory processing// Brain: A Journal of Neurology. -Vol. 140, nr. 5 (2017), s.1337-1350
DOI:
Digital Object Identifier (open in new tab) 10.1093/brain/awx043
Verified by:
Gdańsk University of Technology

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