Search
Dissociative Electron Attachment to 5-Iodo-4-thio-2′-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells
Abstract
In the search for effective radiosensitizers for tumor cells, halogenated uracils have attracted more attention due to their large cross section for dissociation upon the attachment of low-energy electrons. In this study, we investigated dissociative electron attachment (DEA) to 5-iodo-4-thio-2'-deoxyuridine, a potential radiosensitizer using a crossed electron-molecule beam experiment coupled with quadrupole mass spectrometry. The experimental results were supported by calculations on the threshold energies of formed anions and transition state calculations. We show that low-energy electrons with kinetic energies near 0 eV may effectively decompose the molecule upon DEA. The by far most abundant anion observed corresponds to the iodine anion (I-). Due to the associated bond cleavage, a radical site is formed at the C5 position, which may initiate strand break formation if the molecule is incorporated into a DNA strand. Our results reflect the conclusion from previous radiolysis studies with the title compound, suggesting its potential as a radiosensitizer.
Citations
-
2
CrossRef
-
0
Web of Science
-
2
Scopus
Authors (8)
-
Muhammad Saqib
-
Eugene Arthur-Baidoo
-
Farhad Izadi
-
Adrian Szczyrba
-
Magdalena Datta mgr inż.
-
Janusz Rak Prof.
-
Stephan Denifl
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1021/acs.jpclett.3c02219
- License
-
open in new tab
Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
Journal of Physical Chemistry Letters
no. 14,
pages 8948 - 8955,
ISSN: 1948-7185 - Language:
- English
- Publication year:
- 2023
- Bibliographic description:
- Saqib M., Arthur-Baidoo E., Izadi F., Szczyrba A., Datta M., Demkowicz S., Rak J., Denifl S.: Dissociative Electron Attachment to 5-Iodo-4-thio-2′-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells// Journal of Physical Chemistry Letters -,iss. 14 (40) (2023), s.8948-8955
- DOI:
- Digital Object Identifier (open in new tab) 10.1021/acs.jpclett.3c02219
- Sources of funding:
-
- COST_FREE
- Verified by:
- Gdańsk University of Technology
seen 39 times
Recommended for you
Electron-Induced Decomposition of 5-Bromo-4-thiouracil and 5-Bromo-4-thio-2′-deoxyuridine: The Effect of the Deoxyribose Moiety on Dissociative Electron Attachment
- F. Izadi,
- A. Szczyrba,
- M. Datta
- + 4 authors
Hydroperoxyl radical and formic acid formation from common DNA stabilizers upon low energy electron attachment
- A. Ribar,
- S. Huber,
- M. Śmiałek-Telega
- + 5 authors
Intramolecular Proton Transfer in the Radical Anion of Cytidine Monophosphate Sheds Light on the Sensitivities of Dry vs Wet DNA to Electron Attachment-Induced Damage
- L. Chomicz-Mańka,
- A. Czaja,
- K. Falkiewicz
- + 11 authors
Carboxylation Enhances Fragmentation of Furan upon Resonant Electron Attachment
- M. Zawadzki,
- T. F. M. Luxford,
- J. Kočišek