Fatal N-Ethylhexedrone Intoxication - Publication - MOST Wiedzy

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Fatal N-Ethylhexedrone Intoxication

Abstract

N-Ethylhexedrone [2-(ethyloamino)-1-phenylhexan-1-one; α-ethylaminohexanophenone; NEH] is one of the most recent synthetic cathinones that appeared on the illegal market in late 2015. The majority of information concerning the model of consumption of NEH and its impact on the body originates only from self-reports from grey literature websites and drug forums. There are only limited data associated with the concentrations of NEH in blood samples available in the literature. This article presents a case of fatal NEH intoxication and a method for the determination of this substance in whole blood. A 21-year-old man without any diagnosed diseases was admitted to the hospital due to disorientation, aggression and finally loss of consciousness. Hyperthermia (>41°C), tachycardia (>160 beats per minute), tachypnoe (20 breaths per minute), blood pressure (110/60 mmHg) and acute kidney failure were diagnosed. After a few hours of hospitalization, the patient died. A plastic bag with a white powder was found in his underwear. Analysis of the powder by another laboratory revealed cocaine hydrochloride; however, no cocaine or its metabolites were found in the biological material upon testing in our laboratory. Therefore, re-analysis of the powder was performed, and NEH was identified. Liquid-liquid extraction followed by LC-MS-MS analysis were used for the determination of NEH in blood. The validation parameters were as follows: calibration range 1-250 ng/mL, accuracy 106.5-109.9%, precision 3.5-6.3%, recovery 90.1-96.9%, LOD 0.07 ng/mL and LOQ 1 ng/mL. NEH was quantified in the blood at a concentration of 145 ng/mL. Additionally, amphetamine at low concentrations and THC-COOH were detected. Our study provided information on the possible lethal concentration and toxidrome that clinicians can observe for NEH-intoxicated patients and can be helpful during the preparation of toxicology analysis reports for a court of law for proper data.

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Authors (6)

Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
JOURNAL OF ANALYTICAL TOXICOLOGY pages 1 - 6,
ISSN: 0146-4760
Language:
English
Publication year:
2021
Bibliographic description:
Domagalska E., Banaszkiewicz L., Woźniak M., Kata M., Szpiech B., Kaliszan M.: Fatal N-Ethylhexedrone Intoxication// JOURNAL OF ANALYTICAL TOXICOLOGY -, (2021), s.1-6
DOI:
Digital Object Identifier (open in new tab) 10.1093/jat/bkaa159
Verified by:
Gdańsk University of Technology

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