Fragmentomic analysis of biopeptides in silico released from milk proteins - Publication - Bridge of Knowledge

Your account

login

Search

Fragmentomic analysis of biopeptides in silico released from milk proteins

Abstract

The fragmentomic-assisted method was employed to predict the biological potential of peptides derived from milk proteins hydrolyzed by papain and bromelain. Firstly, protein sequences were acquired from the BIOPEP-UWM database and then hydrolyzed by the above enzymes using a BIOPEP-UWM tool called “Enzyme(s) action”. The released peptides were defined as parent peptides and further analyzed for the presence of shorter peptidic regions with documented bioactivity as well as their likelihood to be bioactive. The results revealed the bioactive potential of the released parent peptides. β-Casein was found as the best source of biopeptides. Although this finding is consistent with literature data, the new parent peptide i.e., PVQPFTESQSLTLTDVENLHLPPLLLQSWMHQPHQPLPPTVMFPPQSVLSLSQSK, produced by the action of bromelain might be considered as a new strategic zone due to the presence of multi-active regions. Some parent peptides theoretically produced from milk proteins turned out to be fully bioactive. Despite the usefulness of the tools for peptide bioactivity prediction, the critical thinking while planning the application of such data in future experiments would thus appear to be a worthwhile line of inquiry.

Citations

  • 0

    CrossRef

  • 0

    Web of Science

  • 1

    Scopus

Authors (2)

Cite as

Full text

download paper
downloaded 83 times
Publication version
Accepted or Published Version
DOI:
Digital Object Identifier (open in new tab) 10.31648/pjns.7726
License
Creative Commons: CC-BY-NC-ND open in new tab

Keywords

Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
POLISH JOURNAL OF NATURAL SCIENCES no. 37, pages 125 - 147,
ISSN: 1643-9953
Language:
English
Publication year:
2022
Bibliographic description:
Iwaniak A., Taraszkiewicz A.: Fragmentomic analysis of biopeptides in silico released from milk proteins// POLISH JOURNAL OF NATURAL SCIENCES -Vol. 37,iss. 1 (2022), s.125-147
DOI:
Digital Object Identifier (open in new tab) 10.31648/pjns.7726
Sources of funding:
  • Projekt finansowany w ramach programu Ministra Edukacji i Nauki pod nazwą "Regionalna Inicjatywa Doskonałości" w latach 2019-2022, nr projektu 010/RID/2018/19, kwota finansowania 12 000 000 PLN
  • Projekt finansowany w ramach funduszu Uniwersytetu Warmińsko-Mazurskiego w Olsztynie, nr tematu 17.610.014-110
Verified by:
Gdańsk University of Technology

seen 147 times

Recommended for you

Prediction of Bioactive Peptides From Chicken Feather and Pig Hair Keratins Using In Silico Analysis Based on Fragmentomic Approach

2022

Chicken feather keratin as a source of bioactive peptides useful in prevention of metabolic disorders – in silico and in vitro hydrolysis

2021

The biological role of prolyl oligopeptidase and the procognitive potential of its peptidic inhibitors from food proteins

2024

Rapid Characterization of the Human Breast Milk Lipidome Using a Solid-Phase Microextraction and Liquid Chromatography-Mass Spectrometry-Based Approach.

2017
Meta Tags