Green porous benzamide-like nanomembranes for hazardous cations detection, separation, and concentration adjustment - Publication - MOST Wiedzy

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Green porous benzamide-like nanomembranes for hazardous cations detection, separation, and concentration adjustment

Abstract

Green biomaterials play a crucial role in the diagnosis and treatment of diseases as well as health-related problem-solving. Typically, biocompatibility, biodegradability, and mechanical strength are requirements centered on biomaterial engineering. However, in-hospital therapeutics require an elaborated synthesis of hybrid and complex nanomaterials capable of mimicking cellular behavior. Accumulation of hazardous cations like K+ in the inner and middle ear may permanently damage the ear system. We synthesized nanoplatforms based on Allium noeanum to take the first steps in developing biological porous nanomembranes for hazardous cation detection in biological media. The 1,1,1-tris[[(2′-benzyl-amino-formyl)phenoxy]methyl]ethane (A), 4-amino-benzo-hydrazide (B), and 4-(2-(4-(3-carboxy-propan-amido)benzoyl)hydrazineyl)-4-oxobutanoic acid (B1) were synthesized to obtain green ligands based on 4-X-N-(…(Y(hydrazine-1-carbonyl)phenyl)benzamide, with X denoting fluoro (B2), methoxy (B3), nitro (B4), and phenyl-sulfonyl (B5) substitutes. The chemical structure of ligand-decorated adenosine triphosphate (ATP) molecules (S-ATP) was characterized by FTIR, XRD, AFM, FESEM, and TEM techniques. The cytotoxicity of the porous membrane was patterned by applying different cell lines, including HEK-293, PC12, MCF-7, HeLa, HepG2, and HT-29, to disclose their biological behavior. The morphology of cultured cells was monitored by confocal laser scanning microscopy. The sensitivity of S-ATP to different cations of Na+, Mg2+, K+, Ba2+, Zn2+, and Cd2+ was evaluated by inductively coupled plasma atomic emission spectroscopy (ICP-AES) in terms of extraction efficiency (η). For pH of 5.5, the η of A-based S-ATP followed the order Na+ (63.3%) > Mg2+ (62.1%) > Ba2+ (7.6%) > Ca2+ (5.5%); while for pH of 7.4, Na+ (37.0%) > Ca2+ (33.1%) > K+ (25.7%). The heat map of MTT and dose-dependent evaluations unveiled acceptable cell viability of more than 90%. The proposed green porous nanomembranes would pave the way to use multifunctional green porous nanomembranes in biological membranes.

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Authors (12)

  • Photo of  Navid Rabiee

    Navid Rabiee

    • Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran
  • Photo of  Yousef Fatahi

    Yousef Fatahi

    • Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  • Photo of  Mohsen Asadnia

    Mohsen Asadnia

    • School of Engineering, Macquarie University, Sydney, New South Wales, 2109, Australia
  • Photo of  Hossein Daneshgar

    Hossein Daneshgar

    • Department of Chemistry, Sharif University of Technology, Tehran, Iran
  • Photo of  Mahsa Kiani

    Mahsa Kiani

    • Department of Chemistry, Sharif University of Technology, Tehran, Iran
  • Photo of  Amir Mohammad Ghadiri

    Amir Mohammad Ghadiri

    • Department of Chemistry, Sharif University of Technology, Tehran, Iran
  • Photo of  Monireh Atarod

    Monireh Atarod

    • Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan 87317-51167, Iran
  • Photo of  Amin Hamed Mashhadzadeh

    Amin Hamed Mashhadzadeh

    • Mechanical and Aerospace Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Nur-Sultan 010000, Kazakhstan
  • Photo of  Omid Akhavan

    Omid Akhavan

    • Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran
  • Photo of  Mojtaba Bagherzadeh

    Mojtaba Bagherzadeh

    • Department of Chemistry, Sharif University of Technology, Tehran, Iran
  • Photo of  Eder C. Lima

    Eder C. Lima

    • Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Goncalves 9500, Postal Box, 15003, ZIP, 91501-970, Brazil

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Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
JOURNAL OF HAZARDOUS MATERIALS no. 423,
ISSN: 0304-3894
Language:
English
Publication year:
2022
Bibliographic description:
Rabiee N., Fatahi Y., Asadnia M., Daneshgar H., Kiani M., Ghadiri A. M., Atarod M., Mashhadzadeh A. H., Akhavan O., Bagherzadeh M., Lima E. C., Saeb M.: Green porous benzamide-like nanomembranes for hazardous cations detection, separation, and concentration adjustment// JOURNAL OF HAZARDOUS MATERIALS -Vol. 423, (2022), s.127130-
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.jhazmat.2021.127130
Verified by:
Gdańsk University of Technology

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