High frequency oscillations are associated with cognitive processing in human recognition memory - Publication - MOST Wiedzy


High frequency oscillations are associated with cognitive processing in human recognition memory


High frequency oscillations are associated with normal brain function, but also increasingly recognized as potential biomarkers of the epileptogenic brain. Their role in human cognition has been predominantly studied in classical gamma frequencies (30-100 Hz), which reflect neuronal network coordination involved in attention, learning and memory. Invasive brain recordings in animals and humans demonstrate that physiological oscillations extend beyond the gamma frequency range, but their function in human cognitive processing has not been fully elucidated. Here we investigate high frequency oscillations spanning the high gamma (50-125 Hz), ripple (125-250 Hz) and fast ripple (250-500 Hz) frequency bands using intracranial recordings from 12 patients (five males and seven females, age 21-63 years) during memory encoding and recall of a series of affectively charged images. Presentation of the images induced high frequency oscillations in all three studied bands within the primary visual, limbic and higher order cortical regions in a sequence consistent with the visual processing stream. These induced oscillations were detected on individual electrodes localized in the amygdala, hippocampus and specific neocortical areas, revealing discrete oscillations of characteristic frequency, duration and latency from image presentation. Memory encoding and recall significantly modulated the number of induced high gamma, ripple and fast ripple detections in the studied structures, which was greater in the primary sensory areas during the encoding (Wilcoxon rank sum test, P = 0.002) and in the higher-order cortical association areas during the recall (Wilcoxon rank sum test, P = 0.001) of memorized images. Furthermore, the induced high gamma, ripple and fast ripple responses discriminated the encoded and the affectively charged images. In summary, our results show that high frequency oscillations, spanning a wide range of frequencies, are associated with memory processing and generated along distributed cortical and limbic brain regions. These findings support an important role for fast network synchronization in human cognition and extend our understanding of normal physiological brain activity during memory processing


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  • Photo of  Jan Cymbalnik

    Jan Cymbalnik

  • Photo of  Joseph Matsumoto

    Joseph Matsumoto

  • Photo of  Benjamin H. Brinkmann

    Benjamin H. Brinkmann

  • Photo of  Mark R. Bower

    Mark R. Bower

  • Photo of  Vincent Vasoli

    Vincent Vasoli

  • Photo of  Vladimir Sulc

    Vladimir Sulc

  • Photo of  Fred Meyer

    Fred Meyer

  • Photo of  W.r. Marsh

    W.r. Marsh

  • Photo of  S. M. Stead

    S. M. Stead

  • Photo of  Gregory A. Worrell

    Gregory A. Worrell


Magazine publication
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
Brain: A Journal of Neurology no. 137, pages 2231 - 2244,
ISSN: 0006-8950
Publication year:
Bibliographic description:
Kucewicz M., Cymbalnik J., Matsumoto J., Brinkmann B., Bower M., Vasoli V., Sulc V., Meyer F., Marsh W., Stead S., Worrell G.: High frequency oscillations are associated with cognitive processing in human recognition memory// Brain: A Journal of Neurology. -Vol. 137, nr. 8 (2014), s.2231-2244
Digital Object Identifier (open in new tab) 10.1093/brain/awu149
Verified by:
Gdańsk University of Technology

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