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Abstract
Carnosine, an endogenous dipeptide, has been found to have a plethora of medicinal properties, such as antioxidant, antiageing, and chelating effects, but with one downside: a short half-life. Carnosinases and two hydrolytic enzymes, which remain enigmatic, are responsible for these features. Hence, here we emphasize why research is valuable for better understanding crucial concepts like ageing, neurodegradation, and cancerogenesis, given that inhibition of carnosinases might significantly prolong carnosine bioavailability and allow its further use in medicine. Herein, we explore the literature regarding carnosinases and present a short in silico analysis aimed at elucidating the possible recognition pattern between CN1 and its ligands.
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Authors (6)
-
Serena Vittorio
-
Silva Gervasoni
-
Iwona Inkielewicz-Stępniak
- Gdański Uniwersytet Medyczny
-
Giulio Vistoli
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Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.drudis.2023.103860
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
DRUG DISCOVERY TODAY
no. 29,
ISSN: 1359-6446 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Chmielewska K., Vittorio S., Gervasoni S., Dzierzbicka K., Inkielewicz-Stępniak I., Vistoli G.: Human carnosinases: A brief history, medicinal relevance, and in silico analyses// DRUG DISCOVERY TODAY -Vol. 29,iss. 2 (2024), s.103860-
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.drudis.2023.103860
- Sources of funding:
-
- COST_FREE
- Verified by:
- Gdańsk University of Technology
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