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artykuły w czasopismach

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY no. 189, pages 1 - 17,
ISSN: 0223-5234

Language:

English

Publication year:

2020

Bibliographic description:

Siebert A., Cholewiński G., Trzonkowski P., Rachoń J.: Immunosuppressive properties of amino acid and peptide derivatives of mycophenolic acid// EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY -Vol. 189, (2020), s.1-17

DOI:

Digital Object Identifier (open in new tab) 10.1016/j.ejmech.2020.112091

Bibliography: test

1. CNMR (400 MHz,CD3OD-d4) δ ppm: 10.06 (e), 14.98 (f), 18.98 (γ-T4), 22.31 (d), 24.66 (γ-K4), 28.30 (γ-P4), 29.22 (γ-R4), 31.00 (β-R3), 31.96 (β-A3), 33.95 (δ-K5), 35.06 (β-P3), 36.06 (α-A2), 38.66 (β-K3), 40.56 (h), 42.151 (g), 46.868 (ε-K6), 48.332 (δ-R5) 50.85 (δ-P5), 51.48 (α-R2), 53.29 (OMe), 56.93 (α-K2), 57.81 (α-T2), 60.18 (c), 67.01 (β-T3), 69.37 (b), 106.37 (o), 116.03 (l), 122.37 (r), 123.12 (a), 133.63 (j), 145.31 (m), 159.56 (p), 163.42 (k), 170.96 (n), 170.99 (T1), 172.51 (P1), 172.98 (i) 173.26 (K1), 174.24 (R1,A1); open in new tab
2. 2.2.2.5. Compound MPA-Arg(NO2)-Pro-Lys(Val)-Thr-OMe 3l: Product 3l was obtained with yield 79% as white powder. open in new tab
3. MPA-RT-Val 3l: 1 HNMR (400 MHz, DMSO-d6) δ ppm: 0.807 (d, J=6.9 Hz, 3H, γ-V4), 0.858 (d, J=6.8 Hz, 3H, δ-V5), 1.026 (d, J=4.2 Hz, 3H, γ-T4), 1.279 (m, 2H, γ-K4), 1.369 (m, 3H, δ-K5, β-R3b), 1.461 (m, 3H, β-K3b, γ-R4), 1.627 (m, 2H, β-K3a, β-R3a), 1.714 (s, 3H, f), 1.792 (m, 2H, γ-P4b, β-P3b), 1.861 (m, 2H, γ-P4a, β-V3), 1.977 (m, 1H, β-P3a), 2.061 (s, 3H, e), 2.114 (m, 2H, g), 2.183 (m, 2H, h), 3.005 (m, 5H, α-V2, ε-K6, δ-R5), 3.262 (d, J=6.7 Hz, 2H, d), 3.502 (m, 1H, δ-P5b), 3.604 (m, 1H, δ-P5a), 3.625 (s, 3H, COOMe), 3.676 (s, 3H, c), 4.096 (m, 1H, β-T3), 4.252 (m, 1H, α-T2), 4.269 (m, 1H, α-K2), 4.3 (m, 1H, α-P2), 4.437 (m, 1H, α-R2), 5.096 (t, J=6,5 Hz, 1H, a), 5.222 (s, 2H, b), 7.803 (d, J=8.4 Hz, 1H, α-TNH), 8.022 (m, 3H, α-RNH, α-KNH, ε-KNH);
4. CNMR (400 MHz,CD3OD-d4) δ ppm: 10.05 (e), 14.96 (f), 16.99 (δ-V5), 18.22 (γ-V4), 18.97 (γ-T4), 22.28 (d), 24.65 (γ-K4), 28.49 (γ-P4), 29.22 (γ-R4), 31.05 (β-R3), 31.56 (β-V3), 33.96 (δ-K5), 35.07 (β-P3), 38.68 (β-K3), 40.53 (h), 42.16 (g), 46.648 (ε-K6), 47.904 (δ-R5) 50.74 (δ-P5), 51.46 (α-R2), 53.33 (OMe), 56.93 (α-T2), 57.80 (α-V2), 60.1 (α-P2), 60.18 (c), 67.01 (β-T3), 69.39 (b), 106.35 (o), 116.26 (l), 122.3 (r), 123.08 (a), 133.67 (j), 145.28 (m), 159.57 (p), 163.42 (k), 170.98 (n), 171.12 (T1), 172.43 (P1), 172.97 (i) 173.22 (K1), 173.41 (R1), 174.21 (V1); open in new tab
5. 2.2.2.6. Compound MPA-Arg(NO2)-Pro-Lys(Leu)-Thr-OMe 3m: Product 3m was obtained with yield 91% as white powder. open in new tab
6. MPA-RT-Leu 3m: 1 HNMR (400 MHz, DMSO-d6) δ ppm: 0.77 (m, 6H, δ -L5, ε-L6), 1.014 (m, 3H, γ-T4), 1.22 (m, 10H, γ-K4, β-L3b, β-L3a, δ-K5, β-R3b, β-K3b, γ-R4), 1.59 (m, 3H, β-K3a, β-R3a, γ-L4b), 1.69 (s, 3H, f), 1.79 (m, 3H, γ-P4b, β-P3b, γ-L4a), 1.98 (m, 1H, γ-P4a), 2.05 (s, 3H, e), 2.11 (m, 4H, g, h), 3.03 (m, 2H, ε-K6), 3.11 (m, 2H, δ-R5), 3.25 (d, 2H, J=6.2
7. Hz, d), 3.32 (m, 1H, α-L2), 3.52 (m, 2H, δ-P5b, δ-P5a), 3.60 (s, 3H, COOMe), 3.67 (s, 3H, c), 4.09 (m, 1H, β-T3), 4.24 (m, 2H, α-T2, α-K2), 4.32 (m, 1H, α-P2), 4.43 (m, 1H, α-R2), 5.10 (t, J=6.6 Hz, 1H, a), 5.21 (s, 2H, b), 7.82 (d, J=8.4 Hz, 1H, α-TNH), 8.08 (m, 2H, α-RNH, α-KNH), 8.12 (m, 1H, ε-KNH);
8. CNMR (400 MHz,CD3OD-d4) δ ppm: 11.49 (e), 16.44 (f), 20.48 (γ-T4), 23.39 (d/γ-K4), 23.35 (δ-L5), 24.41 (γ-L4), 24.87 (γ-P4/γ-R4), 28.83 (β-R3), 29.17 (δ-K5), 29.52 (β-P3), 31.81 (β-K3), 34.25 (h), 35.48 (g), 38.81 (ε-K6), 40.54 (δ-R5) 43.17 (β-L3), 47.18 (δ-P5), 50.26 (α-R2), 52.28 (OMe), 52.74 (α-L2) 52.85 (α-K2), 58.13 (α-T2), 59.58 (α-P2), 60.95 (c), 66.76 (β-T3), 68.98 (b), 122.94 (o/a), 146.11 (m), 159.72 (p), 162.98 (k), 170.48 (n), 171.43 (T1), 171.82 (P1), 172.14 (i) 172.59 (K1); open in new tab
9. 2.2.2.7. Compound MPA-Arg(NO2)-Pro-Lys(Ile)-Thr-OMe 3n: Product 3n was obtained with yield 84% as white powder. open in new tab
10. MPA-RT-Ile 3n: 1 HNMR (400 MHz, DMSO-d6) δ ppm: 0.806 (m, 6H, δ-I5, ε-I6), 1.041 (d, J=6.3 Hz, 3H, γ-T4), 1.078 (m, 2H, γ-I4), 1.273 (m, 2H, γ-K4), 1.393 (m, 3H, δ-K5, β-R3b), 1.459 (m, 3H, β-K3b, γ-R4), 1.634 (m, 3H, β-K3a, β-R3a, β-I3), 1.727 (s, 3H, f), 1.804 (m, 2H, γ-P4b, β-P3b), 1.894 (m, 2H, γ-P4a, β-T3), 1.995 (m, 1H, β-P3a), 2.071 (s, 3H, e), 2.129 (m, 4H, g, h), 3.007 (m, 5H, α-I2, ε-K6, δ-R5), 3.272 (d, J=6.5 Hz, 2H, d), 3.515 (m, 1H, δ-P5b), 3.617 (m, 1H, δ-P5a), 3.625 (s, 3H, COOMe), 3.687 (s, 3H, c), 4.103 (m, 1H, β-T3), 4.25 (m, 2H, α-T2, α-K2), 4.339 (m, 1H, α-P2), 4.444 (m, 1H, α-R2), 5.142 (t, J=6.7 Hz, 1H, a), 5.228 (s, 2H, b), 7.817 (d, J=8.2 Hz, 1H, α-TNH), 8.018 (m, 3H, α-RNH, α-KNH, ε-KNH);
11. CNMR (400 MHz,CD3OD-d4) δ ppm: 10.07 (e), 10.45 (δ-I5), 14.45 (ε-I6), 14.93 (f), 18.97 (γ-T4), 22.29 (d), 24.22 (γ-I4), 24.66 (γ-K4), 28.48 (γ-P4), 29.22 (γ-R4), 31.04 (β-R3), 33.97 (δ-K5), 35.08 (β-P3), 38.24 (β-I3), 38.69 (β-K3), 40.53 (h), 42.16 (g), 46.894 (ε-K6), 48.357 (δ-R5) 50.76 (δ-P5), 51.47 (α-R2), 53.35 (OMe), 56.93 (α-T2), 57.81 (α-I2), 59.08 (α-K2), 60.11 (α-P2), 60.18 (c), 67.02 (β-T3), 69.39 (b), 106.35 (o), 116.2 (l), 122.32 (r), 123.09 (a), 133.66 (j), 145.29 (m), 159.56 (p), 163.42 (k), 170.99 (n), 171.14 (T1), 172.45 (P1), 172.97 (i) 173.23 (K1), 173.42 (R1), 174.21 (I1); open in new tab
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