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Influence of a lipid bilayer on the conformational behavior of amphotericin B derivatives - A molecular dynamics study.
Abstract
Amphotericin B (AmB) is an effective but very toxic antifungal antibiotic. In our laboratory a series of AmB derivatives of improved selectivity of action was synthesized and tested. To understand molecular basis of this improvement, comparative conformational studies of amphotericin B and its two more selectivederivatives were carried out in an aqueous solution and in a lipid membrane. These molecular simulation studies revealed that within a membrane environment the conformational behavior of the derivatives differs significantly from the one observed for the parent molecule. Possible reasons for such a difference are analyzed. Furthermore, we hypothesize that the observed conformational transition within the polar head of AmB derivatives may lead to destabilization of antibiotic-induced transmembrane channels. Consequently, the selective toxicity of the derivatives should increase as ergosterol-rich liquid-ordered domains are more rigid and conformationally ordered than their cholesterol-containing counterparts, and as such may better support less stable channel structure.
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- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
BIOPHYSICAL CHEMISTRY
no. 141,
pages 105 - 116,
ISSN: 0301-4622 - Language:
- English
- Publication year:
- 2009
- Bibliographic description:
- Czub J., Neumann A., Borowski E., Bagiński M.: Influence of a lipid bilayer on the conformational behavior of amphotericin B derivatives - A molecular dynamics study.// BIOPHYSICAL CHEMISTRY. -Vol. 141, nr. iss. 1 (2009), s.105-116
- Verified by:
- Gdańsk University of Technology
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