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Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics – synthesis and properties
Abstract
Glucosamine-6-phosphate synthase (GlcN-6-P synthase) is known as a promising target for antimicrobial agents and antidiabetics. Several compounds of natural or synthetic origin have been identified as inhibitors of this enzyme. This set comprises highly selective L-glutamine, amino sugar phosphate or transition state intermediate cis-enolamine analogues. Relatively low antimicrobial activity of these inhibitors, poorly penetrating microbial cell membranes, has been improved using the pro-drug approach. On the other hand, a number of heterocyclic and polycyclic compounds demonstrating antimicrobial activity have been presented as putative inhibitors of the enzyme, based on the results of molecular docking to GlcN-6-P synthase matrix. The most active compounds of this group could be considered promising leads for development of novel antimicrobial drugs or antidiabetics, provided their selective toxicity is confirmed.
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1080/14756366.2022.2096018
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
no. 37,
pages 1928 - 1956,
ISSN: 1475-6366 - Language:
- English
- Publication year:
- 2022
- Bibliographic description:
- Stefaniak J., Nowak M., Wojciechowski M., Milewski S., Skwarecki A.: Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics – synthesis and properties// JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY -Vol. 37,iss. 1 (2022), s.1928-1956
- DOI:
- Digital Object Identifier (open in new tab) 10.1080/14756366.2022.2096018
- Sources of funding:
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- Free publication
- Verified by:
- Gdańsk University of Technology
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