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Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics – synthesis and properties

Abstract

Glucosamine-6-phosphate synthase (GlcN-6-P synthase) is known as a promising target for antimicrobial agents and antidiabetics. Several compounds of natural or synthetic origin have been identified as inhibitors of this enzyme. This set comprises highly selective L-glutamine, amino sugar phosphate or transition state intermediate cis-enolamine analogues. Relatively low antimicrobial activity of these inhibitors, poorly penetrating microbial cell membranes, has been improved using the pro-drug approach. On the other hand, a number of heterocyclic and polycyclic compounds demonstrating antimicrobial activity have been presented as putative inhibitors of the enzyme, based on the results of molecular docking to GlcN-6-P synthase matrix. The most active compounds of this group could be considered promising leads for development of novel antimicrobial drugs or antidiabetics, provided their selective toxicity is confirmed.

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Keywords

Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY no. 37, pages 1928 - 1956,
ISSN: 1475-6366
Language:
English
Publication year:
2022
Bibliographic description:
Stefaniak J., Nowak M., Wojciechowski M., Milewski S., Skwarecki A.: Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics – synthesis and properties// JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY -Vol. 37,iss. 1 (2022), s.1928-1956
DOI:
Digital Object Identifier (open in new tab) 10.1080/14756366.2022.2096018
Verified by:
Gdańsk University of Technology

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