Injectable bone cement based on magnesium potassium phosphate and cross-linked alginate hydrogel designed for minimally invasive orthopedic procedures - Publication - Bridge of Knowledge

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Injectable bone cement based on magnesium potassium phosphate and cross-linked alginate hydrogel designed for minimally invasive orthopedic procedures

Abstract

Bone cement based on magnesium phosphate has extremely favorable properties for its application as a bioactive bone substitute. However, further improvement is still expected due to difficult injectability and high brittleness. This paper reported the preparation of novel biocomposite cement, classified as dual-setting, obtained through ceramic hydration reaction and polymer cross-linking. Cement was composed of magnesium potassium phosphate and sodium alginate cross-linked with calcium carbonate and gluconolactone. The properties of the obtained composite material and the influence of sodium alginate modification on cement reaction were investigated. Our results indicated that proposed cements have several advantages compared to ceramic cement, like shortened curing time, diverse microstructure, increased wettability and biodegradability and improved paste cohesion and injectability. The magnesium phosphate cement with 1.50% sodium alginate obtained using a powder-to-liquid ratio of 2.5 g/mL and cross-linking ratio 90/120 of GDL/CC showed the most favorable properties, with no adverse effect on mechanical strength and osteoblasts cytocompatibility. Overall, our research suggested that this novel cement might have promising medical application prospects, especially in minimally invasive procedures.

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Details

Category:
Articles
Type:
artykuły w czasopismach
Published in:
Scientific Reports no. 14,
ISSN: 2045-2322
Language:
English
Publication year:
2024
Bibliographic description:
Wekwejt M., Jesiołkiewicz R., Mielewczyk-Gryń A., Kozień D., Ronowska A., Kozłowska J., Gbureck U.: Injectable bone cement based on magnesium potassium phosphate and cross-linked alginate hydrogel designed for minimally invasive orthopedic procedures// Scientific Reports -,iss. 1 (2024),
DOI:
Digital Object Identifier (open in new tab) 10.1038/s41598-024-70984-5
Sources of funding:
  • IDUB
Verified by:
Gdańsk University of Technology

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