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Iso-Partricin, an Aromatic Analogue of Amphotericin B: How Shining Light on Old Drugs Might Help Create New Ones
Abstract
Partricin is a heptaene macrolide antibiotic complex that exhibits exceptional antifungal activity, yet poor selective toxicity, in the pathogen/host system. It consists of two compounds, namely partricin A and B, and both of these molecules incorporate two cis-type bonds within their heptaenic chromophores: 28Z and 30Z. In this contribution, we have proven that partricins are susceptible to a chromophore-straightening photoisomerization process. The occurring 28Z→28E and 30Z→30E switches are irreversible in given conditions, and they are the only structural changes observed during the experiment. The obtained all-trans partricin’s derivatives, namely iso-partricins A and B, exhibit very promising features, potentially resulting in the improvement of their selective toxicity.
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Authors (6)
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Witold Andrałojć dr
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- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/antibiotics10091102
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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Antibiotics-Basel
no. 10,
ISSN: 2079-6382 - Language:
- English
- Publication year:
- 2021
- Bibliographic description:
- Szczeblewski P., Górska J., Andrałojć W., Janke P., Wąsik K., Laskowski T.: Iso-Partricin, an Aromatic Analogue of Amphotericin B: How Shining Light on Old Drugs Might Help Create New Ones// Antibiotics-Basel -Vol. 10,iss. 9 (2021), s.1102-
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/antibiotics10091102
- Sources of funding:
- Verified by:
- Gdańsk University of Technology
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