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Microemulsion Delivery Systems with Low Surfactant Concentrations: Optimization of Structure and Properties by Glycol Cosurfactants
Abstract
Extensive use of microemulsions as delivery systems raises interest in the safe ingredients that can form such systems. Here, we assessed the use of two glycols, i.e., propylene glycol and pentylene glycol, and their mixtures to manipulate the properties and structure of microemulsions. Obtained systems with glycols were extensively characterized in terms of capacity to incorporate water phase, droplet size, polydispersity, structure type, and rheological and thermal properties. The results of these studies indicate that the composition, structure, and viscosity of the microemulsions can be changed by appropriate quantification of glycols. It has been shown that the type of glycol used and its amount may favor or worsen the formation of microemulsions with the selected oils. In addition, a properly selected composition of oils and glycols resulted in the formation of microemulsions with a reduced content of surfactants and consequently improved the safety of using microemulsions as delivery systems.
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1021/acs.molpharmaceut.2c00599
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
MOLECULAR PHARMACEUTICS
no. 20,
pages 232 - 240,
ISSN: 1543-8384 - Language:
- English
- Publication year:
- 2023
- Bibliographic description:
- Szumała P., Mania S., Makurat-Kasprolewicz B., Kaplińska J.: Microemulsion Delivery Systems with Low Surfactant Concentrations: Optimization of Structure and Properties by Glycol Cosurfactants// MOLECULAR PHARMACEUTICS -Vol. 20,iss. 1 (2023), s.232-240
- DOI:
- Digital Object Identifier (open in new tab) 10.1021/acs.molpharmaceut.2c00599
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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