Molecular modeling and evaluation of novel dibenzopyrrole derivatives as telomerase inhibitors and potential drug for cancer therapy - Publication - Bridge of Knowledge

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Molecular modeling and evaluation of novel dibenzopyrrole derivatives as telomerase inhibitors and potential drug for cancer therapy

Abstract

During previous years, many studies on synthesis, as well as on anti-tumor, anti-inflammatory and anti-bacterial activities of the pyrazole derivatives have been described. Certain pyrazole derivatives exhibit important pharmacological activities and have proved to be useful template in drug research. Considering importance of pyrazole template, in current work the series of novel inhibitors were designed by replacing central ring of acridine with pyrazole ring. These heterocyclic compounds were proposed as a new potential base for telomerase inhibitors. Obtained dibenzopyrrole structure was used as a novel scaffold structure and extension of inhibitors was done by different functional groups. Docking of newly designed compounds in the telomerase active site (telomerase catalytic subunit TERT) was carried out. All dibenzopyrrole derivatives were evaluated by three docking programs: CDOCKER, Ligandfit docking (Scoring Functions) and AutoDock. Compound C_9g, C_9k and C_9l performed best in comparison to all designed inhibitors during the docking in all methods and in interaction analysis. Introduction of pyrazole and extension of dibenzopyrrole in compounds confirm that such compound may act as potential telomerase inhibitors.

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Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
IEEE-ACM Transactions on Computational Biology and Bioinformatics no. 11, edition 6, pages 1196 - 1207,
ISSN: 1545-5963
Language:
English
Publication year:
2014
Bibliographic description:
Kalathiya U., Padariya M., Bagiński M.: Molecular modeling and evaluation of novel dibenzopyrrole derivatives as telomerase inhibitors and potential drug for cancer therapy// IEEE-ACM Transactions on Computational Biology and Bioinformatics. -Vol. 11, iss. 6 (2014), s.1196-1207
DOI:
Digital Object Identifier (open in new tab) 10.1109/tcbb.2014.2326860
Verified by:
Gdańsk University of Technology

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