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Network oscillations modulate interictal epileptiform spike rate during human memory

Abstract

Eleven patients being evaluated with intracranial electroencephalography for medically resistant temporal lobe epilepsy participated in a visual recognition memory task. Interictal epileptiform spikes were manually marked and their rate of occurrence compared between baseline and three 2 s periods spanning a 6 s viewing period. During successful, but not unsuccessful, encoding of the images there was a significant reduction in interictal epileptiform spike rate in the amygdala, hippocampus, and temporal cortex. During the earliest encoding period (0-2000 ms after image presentation) in these trials there was a widespread decrease in the power of theta, alpha and beta band local field potential oscillations that coincided with emergent focal gamma frequency activity. Interictal epileptiform spike rate correlated with spectral band power changes and broadband (4-150 Hz) desynchronization, which predicted significant reduction in interictal epileptiform spike rate. Spike-triggered averaging of the field potential power spectrum detected a burst of low frequency synchronization 200 ms before the interictal epileptiform spikes that arose during this period of encoding. We conclude that interictal epileptiform spikes are modulated by the patterns of network oscillatory activity that accompany human memory offering a new mechanistic insight into the interplay of cognitive processing, local field potential dynamics and interictal epileptiform spike generation.

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Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
Brain: A Journal of Neurology no. 136, edition 8, pages 2444 - 2456,
ISSN: 0006-8950
Language:
English
Publication year:
2013
Bibliographic description:
Matsumoto J., Stead M., Kucewicz M., Matsumoto A., Peters P., Brinkmann B., Danstrom J., Goerss S., Marsh W., Meyer F., Worrell G.: Network oscillations modulate interictal epileptiform spike rate during human memory// Brain: A Journal of Neurology. -Vol. 136, iss. 8 (2013), s.2444-2456
DOI:
Digital Object Identifier (open in new tab) 10.1093/brain/awt159.epub2013jun25.
Verified by:
Gdańsk University of Technology

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