Pathological and physiological high-frequency oscillations in focal human epilepsy - Publication - MOST Wiedzy

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Pathological and physiological high-frequency oscillations in focal human epilepsy

Abstract

High-frequency oscillations (HFO; gamma: 40-100 Hz, ripples: 100-200 Hz, and fast ripples: 250-500 Hz) have been widely studied in health and disease. These phenomena may serve as biomarkers for epileptic brain; however, a means of differentiating between pathological and normal physiological HFO is essential. We categorized task-induced physiological HFO during periods of HFO induced by a visual or motor task by measuring frequency, duration, and spectral amplitude of each event in single trial time-frequency spectra and compared them to pathological HFO similarly measured. Pathological HFO had higher mean spectral amplitude, longer mean duration, and lower mean frequency than physiological-induced HFO. In individual patients, support vector machine analysis correctly classified pathological HFO with sensitivities ranging from 70-98% and specificities >90% in all but one patient. In this patient, infrequent high-amplitude HFO were observed in the motor cortex just before movement onset in the motor task. This finding raises the possibility that in epileptic brain physiological-induced gamma can assume higher spectral amplitudes similar to those seen in pathologic HFO. This method if automated and validated could provide a step towards differentiating physiological HFO from pathological HFO and improving localization of epileptogenic brain.

Citations

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Authors

  • Photo of  Andrew Matsumoto

    Andrew Matsumoto

  • Photo of  Benjamin Brinkmann

    Benjamin Brinkmann

  • Photo of  S. Matthew Stead

    S. Matthew Stead

  • Photo of  Joseph Matsumoto

    Joseph Matsumoto

  • Photo of  W. Richard Marsh

    W. Richard Marsh

  • Photo of  Frederic Meyer

    Frederic Meyer

  • Photo of  Gregory Worrell

    Gregory Worrell

Details

Category:
Magazine publication
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
JOURNAL OF NEUROPHYSIOLOGY no. 110, edition 8, pages 1958 - 1964,
ISSN: 0022-3077
Language:
English
Publication year:
2013
Bibliographic description:
Matsumoto A., Brinkmann B., Stead S., Matsumoto J., Kucewicz M., Marsh W., Meyer F., Worrell G.: Pathological and physiological high-frequency oscillations in focal human epilepsy// JOURNAL OF NEUROPHYSIOLOGY. -Vol. 110, iss. 8 (2013), s.1958-1964
DOI:
Digital Object Identifier (open in new tab) 10.1152/jn.00341.2013
Verification:
Gdańsk University of Technology

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