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Abstract
High-frequency oscillations (HFO; gamma: 40-100 Hz, ripples: 100-200 Hz, and fast ripples: 250-500 Hz) have been widely studied in health and disease. These phenomena may serve as biomarkers for epileptic brain; however, a means of differentiating between pathological and normal physiological HFO is essential. We categorized task-induced physiological HFO during periods of HFO induced by a visual or motor task by measuring frequency, duration, and spectral amplitude of each event in single trial time-frequency spectra and compared them to pathological HFO similarly measured. Pathological HFO had higher mean spectral amplitude, longer mean duration, and lower mean frequency than physiological-induced HFO. In individual patients, support vector machine analysis correctly classified pathological HFO with sensitivities ranging from 70-98% and specificities >90% in all but one patient. In this patient, infrequent high-amplitude HFO were observed in the motor cortex just before movement onset in the motor task. This finding raises the possibility that in epileptic brain physiological-induced gamma can assume higher spectral amplitudes similar to those seen in pathologic HFO. This method if automated and validated could provide a step towards differentiating physiological HFO from pathological HFO and improving localization of epileptogenic brain.
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Authors (8)
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Andrew Matsumoto
- Mayo Clinic Department of Neurology, Mayo Systems Electrophysiology Laborator
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Benjamin Brinkmann
- Mayo Clinic Department of Neurology, Mayo Systems Electrophysiology Laborator
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S. Matthew Stead
- Mayo Clinic Department of Neurology, Mayo Systems Electrophysiology Laborator
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Joseph Matsumoto
- Mayo Clinic Department of Neurology, Mayo Systems Electrophysiology Laborator
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Michał Tomasz Kucewicz dr
- Mayo Clinic Department of Neurology, Mayo Systems Electrophysiology Laborator
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W. Richard Marsh
- Mayo Clinic Department of Neurosurgery, Mayo Systems Electrophysiology Laboratory
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Frederic Meyer
- Mayo Clinic Department of Neurosurgery, Mayo Systems Electrophysiology Laboratory
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Gregory Worrell
- Mayo Clinic Department of Neurology, Mayo Systems Electrophysiology Laborator
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Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
JOURNAL OF NEUROPHYSIOLOGY
no. 110,
edition 8,
pages 1958 - 1964,
ISSN: 0022-3077 - Language:
- English
- Publication year:
- 2013
- Bibliographic description:
- Matsumoto A., Brinkmann B., Stead S., Matsumoto J., Kucewicz M., Marsh W., Meyer F., Worrell G.: Pathological and physiological high-frequency oscillations in focal human epilepsy// JOURNAL OF NEUROPHYSIOLOGY. -Vol. 110, iss. 8 (2013), s.1958-1964
- DOI:
- Digital Object Identifier (open in new tab) 10.1152/jn.00341.2013
- Verified by:
- Gdańsk University of Technology
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