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Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?
Abstract
Intestinal bacteria are equipped with an enzyme apparatus that is involved in the active biotrans-formation of xenobiotics, including drugs. Pharmacomicrobiomics, a new area of pharmacology, analyses interactions between bacteria and xenobiotics. However, there is another side to the coin. Pharmacotherapeutic agents can significantly modify the microbiota, which consequently affects their efficacy. In this review, we comprehensively gathered scientific evidence on the interplay between anticancer therapies and gut microbes. We also underlined how such interactions might impact the host response to a given therapy. We discuss the possibility of modulating the gut microbiota to increase the effectiveness/decrease the incidence of adverse events during tumor therapy. The anticipation of the future brings new evidence that gut microbiota is a target of interest to increase the efficacy of therapy.
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Authors (8)
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Karolina Kaźmierczak-Siedlecka
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Nikola Bulman
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Paweł Ulasiński
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Bartosz Kamil Sobocki
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Karol Polom
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Luigi Marano
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Karolina Skonieczna-Żydecka
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1080/19490976.2023.2281017
- License
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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Gut Microbes
no. 15,
pages 1 - 20,
ISSN: 1949-0976 - Language:
- English
- Publication year:
- 2023
- Bibliographic description:
- Kaźmierczak-Siedlecka K., Bulman N., Ulasiński P., Sobocki B. K., Polom K., Marano L., Kalinowski L., Skonieczna-Żydecka K.: Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?// Gut Microbes -Vol. 15,iss. 2 (2023), s.1-20
- DOI:
- Digital Object Identifier (open in new tab) 10.1080/19490976.2023.2281017
- Sources of funding:
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- This research was funded by the Polish Ministry of Education and Science, grant no. 10/E-389/SPUB/SP/2020
- Verified by:
- Gdańsk University of Technology
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