Abstract

Fetal growth restriction (FGR) is mainly caused by failure of the uteroplacental unit. The
exact pathogenesis remains unclear. The cause is thought to be related to abnormal platelet activation,
which may result in microthrombus formation in the small vessels of the placenta. Reactive oxygen
species (ROS) may initiate the pathological process of platelet activation. This study aimed to evaluate
selected platelet parameters in pregnancy complicated by FGR and relate them to the severity of
hemodynamic abnormalities. A total of 135 women (pregnant with FGR, with an uncomplicated
pregnancy, and non-pregnant) were enrolled to study different platelet parameters: count (PLT), mean
volume (MPV), ROS levels, intracellular oxygen level, oxygen consumption, and aggregation indices.
No abnormalities in PLT and MPV were found in the FGR group, although it revealed increased ROS
levels in platelets, lower platelet oxygen consumption, and intraplatelet deprivation. Aggregation
parameters were similar as in uncomplicated pregnancy. No significant relationships were observed
between hemodynamic abnormalities and the studied parameters. Platelets in pregnancies compli-
cated by FGR may reveal an impaired oxidative metabolism, which may, in turn, lead to oxidative
stress and, consequently, to an impaired platelet function. This study adds to the understanding of
the role of platelets in the etiology of FGR.

Citations

Authors (5)