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Recent developmentsinthesynthesisand biological activityofacridine/acridoneanalogues

Abstract

Many people in the world struggle with cancer or bacterial, parasitic, viral, Alzheimer's and other diseases. Therefore, many scientists seek new, more effective, more selective and less toxic drugs. Acridine/acridone derivatives constitute a class of compounds with a broad spectrum of biological activity and are of great interest to scientists. Todate, many acridine/acridone analogues have been obtained,which, inter alia, exhibit antitumour antimicrobial and antiviral activities and are applicable in the treatment of Alzheimer's disease. However, inmanycases, the irclinical application is limited and excluded because of side effects. In this survey, we describe acridine and acridone derivatives reported since 2013, methods of their synthesis and their potential clinical applications.

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Details

Category:
Magazine publication
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
RSC Advances no. 26, pages 1 - 29,
ISSN: 2046-2069
Language:
English
Publication year:
2017
Bibliographic description:
Gensicka-Kowalewska M., Cholewiński G., Dzierzbicka K.: Recent developmentsinthesynthesisand biological activityofacridine/acridoneanalogues// RSC Advances. -Vol. 26, (2017), s.1-29
DOI:
Digital Object Identifier (open in new tab) 10.1039/c7ra01026e
Verification:
Gdańsk University of Technology

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