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Abstract
Cocoa polyphenols play an important role in protection against diseases in which oxidative stress is implicated as a causal or contributing factor. The main aim of this study was to elucidate the influence of different cocoa extracts and main cocoa bioactive compound (–)-epicatechin on cell growth and support of antioxidant cellular barrier in colon adenocarcinoma cell line model (HT29). Results show that the tested cocoa bioactivity results from concerted interactions between epicatechin and other components. Hence, cocoa is a very good example which supports the food synergy concept that is attracting growing interest.
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Authors (4)
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Vanja Todorović
- University of Belgrade Faculty of Pharmacy
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Sladana Sobajić
- University of Belgrade Faculty of Pharmacy
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- Category:
- Articles
- Type:
- publikacja w in. zagranicznym czasopiśmie naukowym (tylko język obcy)
- Published in:
-
Proceedings
no. 11,
pages 1 - 5,
ISSN: - Language:
- English
- Publication year:
- 2019
- Bibliographic description:
- Todorović V., Baranowska M., Sobajić S., Bartoszek-Pączkowska A.. REGULATION OF CELLULAR REDOX HOMEOSTASIS BY (-)-EPICATECHIN AND COCOA EXTRACTS – PILOT STUDY. Proceedings, 2019, Vol. 11, iss. 1, s.1-5
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/proceedings2019011006
- Bibliography: test
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- Liu, H.R. Potential synergy of phytochemicals in cancer prevention: Mechanism of action. J. Nutr. 2004, 134, 3479S-3485S, doi:10.1093/jn/134.12.3479S. open in new tab
- Katz, D.L.; Doughty, K.; Ali, A. Cocoa and chocolate in human health and disease. Antioxid. Redox Signal 2011, 15, 2799-2811, doi:10.1089/ars.2010.3697. open in new tab
- Panneerselvam, M.; Tsutsumi, Y.M.; Bonds, J.A.; Horikawa, Y.T.; Saldana, M.; Dalton, N.D.; Head, B.P.; Patel, P.M.; Roth, D.M.; Patel, H.H. Dark chocolate receptors: Epicatechin-induced cardiac protection is dependent on delta-opioid receptor stimulation. Am. J. Physiol. Heart Circ. Physiol. 2010, 299, H1604-H1609, doi:10.1152/ajpheart.00073.2010. open in new tab
- Koss-Mikołajczyk, I.; Baranowska, M.; Todorovic, V.; Albini, A.; Sansone, C.; Andreoletti, P.; Cherkaoui-Malki, M.; Lizard, G.; Sobajic, S.; Bartoszek, A. Prophylaxis of non-communicable diseases: Why fruits and vegetables may be better chemopreventive agents than dietary supplements based on isolated phytochemicals? Curr. Pharm. Des. just accepted. open in new tab
- Baranowska, M.; Suliborska, K.; Chrzanowski, W.; Kusznierewicz, B.; Namieśnik, J.; Bartoszek, A. The relationship between standard reduction potentials of catechins and biological activities involved in redox control. Redox Biol. 2018, 17, 355-366, doi:10.1016/j.redox.2018.05.005. open in new tab
- Verified by:
- Gdańsk University of Technology
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Regulation of Cellular Redox Homeostasis by (–)-Epicatechin and Cocoa Extracts—A Pilot Study
- V. Todorović,
- M. Baranowska,
- S. Sobajić
2019