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Short Term Monitor of Photodegradation Processes in Ranitidine Hydrochloride Observed by FTIR and ATR FTIR
Abstract
The effects of degradation of ranitidine hydrochloride exposed to UVB radiation (l = 310 nm) and oxygen in a weathering chamber were studied by Fourier Transform Infrared spectroscopy (FTIR) and Attenuated Total Reflectance Fourier Transform
Infrared spectroscopy (ATR-FTIR). ATR-FTIR profile indicated that the degradation was spatially heterogeneous. Significant amounts of photoproducts were detected only in a directly irradiated layer. Major damage/change was reflected in the appearance
of broad, extended group of signals near the wavenumber 3600-3200 cm-1 or/and 3500-3400 cm-1. We examined whether FTIR-ATR technique is a great tool to observe the simplest and the first changes on the surface of a substance in powder.
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Details
- Category:
- Magazine publication
- Type:
- Magazine publication
- Published in:
-
JOURNAL OF FOOD AND DRUG ANALYSIS
no. 17,
edition 5,
pages 342 - 347,
ISSN: 1021-9498 - Publication year:
- 2009
- Verified by:
- No verification
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