Search
Abstract
Background This study examines self-reported sleep alterations in treatment-resistant depression (TRD) inpatients following intravenous ketamine administration. Methods This is a post-hoc analysis of a naturalistic observational study, which enrolled 28 inpatients with treatment-resistant major depressive disorder and analyzed self-reported sleep changes (items 1–4; ‘insomnia’, ‘nighttime restlessness’, ‘early morning waking’, ‘hypersomnia’) in Inventory of Depressive Symptomatology 30-item (IDS SR-30) in responders and non-responders stratified per Montgomery-Åsberg Depression Rating Scale (MADRS) during short-term ketamine treatment. Results Responders, as well as non-responders, did not experience significant changes in IDS SR-30 sleep items (‘insomnia’, ‘nighttime restlessness’, ‘early morning waking’, ‘hypersomnia’) (p’s > 0.05) at 7-day follow-up after eight intravenous ketamine infusions as compared to baseline. Conclusion Neither responders, nor non-responders reported any significant alterations in sleep patterns during ketamine infusions. These findings are not in line with current literature, as so far modest improvements in sleep during ketamine treatment have been reported. Results should be interpreted with caution, primarily due to the small sample size.
Citations
-
0
CrossRef
-
0
Web of Science
-
0
Scopus
Authors (4)
-
Aleksander Kwaśny
-
Wiesław Jerzy Cubała
-
Adam Włodarczyk
Cite as
Full text
full text is not available in portal
Keywords
Details
- Category:
- Articles
- Type:
- artykuły w czasopismach dostępnych w wersji elektronicznej [także online]
- Published in:
-
Pharmacological Reports
ISSN: 1734-1140 - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Kwaśny A., Cubała W. J., Włodarczyk A., Pastuszak K., Sleep alterations in treatment-resistant depression patients undergoing ketamine treatment, Pharmacological Reports, 2024,10.1007/s43440-024-00641-1
- DOI:
- Digital Object Identifier (open in new tab) 10.1007/s43440-024-00641-1
- Sources of funding:
-
- Opłaty OA poniesione przez autorów spoza PG
- Verified by:
- Gdańsk University of Technology
seen 41 times
Recommended for you
Differential expression profile between amygdala and blood during chronic lithium treatment in a rat model of depression – a pilot study
- K. Sakrajda,
- D. Szczepankiewicz,
- J. Nowakowska
- + 7 authors
Underdiagnosis of Major Depressive Episodes in Hemodialysis Patients: The Need for Screening and Patient Education.
- W. Orzechowski,
- W. Buczek,
- J. E. Szczerba
- + 6 authors
Ketamine—New Possibilities in the Treatment of Depression: A Narrative Review
- M. Kowalczyk,
- E. Kowalczyk,
- P. Kwiatkowski
- + 3 authors
The interplay between Disinhibition and Present-Hedonistic time perspective in the relation between Borderline Personality Organization and depressive symptoms
- A. Zajenkowska,
- I. Nowakowska,
- I. Kaźmierczak
- + 5 authors