Special techniques and future perspectives: Simultaneous macro- and micro-electrode recordings

Michał Tomasz Kucewicz; Brent M. Berry; Gregory A. Worrell

Special techniques and future perspectives: Simultaneous macro- and micro-electrode recordings

Abstract

There are many approaches to studying the inner workings of the brain and its highly interconnected circuits. One can look at the global activity in different brain structures using non-invasive technologies like positron emission tomography (PET) or functional magnetic resonance imaging (fMRI), which measure physiological changes, e.g. in the glucose uptake or blood flow. These can be very effectively used to localize active patches of brain tissue with up to millimeter-scale resolution but provide limited insight into the processes underlying this activity. At the heart of brain processes lies synchronized activity of neurons, neuronal assemblies and the wide-spread connections of neuronal networks, which give rise to the electrical activity recorded in the scalp electroencephalogram (EEG), cortical field oscillations in the electrocorticogram (ECoG), and the local field potential (LFP) and action potentials. This large scale of brain electrophysiology across a wide range of spatial and temporal scales presents significant technical challenges for the methods used to probe the activity of neural networks.

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Category:

Monographic publication

Type:

rozdział, artykuł w książce - dziele zbiorowym /podręczniku w języku o zasięgu międzynarodowym

Title of issue:

Invasive studies of the human epileptic brain

Language:

English

Publication year:

2019

Bibliographic description:

Kucewicz M. T., Berry B., Worrell G.: Special techniques and future perspectives: Simultaneous macro- and micro-electrode recordings// Invasive studies of the human epileptic brain/ ed. SamdenD. Lhatoo, Philippe Kahane, Hans O. Luders Oxford: Oxford University Press, 2019, s.-

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