Sulfonamides with hydroxyphenyl moiety: Synthesis, structure, physicochemical properties, and ability to form complexes with Rh(III) ion

Małgorzata Gawrońska; Mateusz Kowalik; Joanna Duch; Katarzyna Kazimierczuk; Mariusz Makowski

doi:10.1016/j.poly.2022.115865

Sulfonamides with hydroxyphenyl moiety: Synthesis, structure, physicochemical properties, and ability to form complexes with Rh(III) ion

Abstract

Sulfonamides are the first successfully synthesized antimicrobial drugs. The mechanism of sulfonamides’ antimicrobial action involves competitive inhibition of folic acid synthesis and prevention of the growth and reproduction of bacteria. Even though they have been applied in therapy for more than 75 years, sulfonamides are still the drugs of choice for the treatment of various diseases. The aim of this work was to synthesize and characterize two new sulfonamides hydroxyphenyl moiety and investigate their ability to form complexes with Rh(III). The results of recent studies indicate an increased interest in the application of potential platinum-group metal ion complexes as an alternative, promising candidates for anticancer and antimicrobial drugs.

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Authors (5)

Małgorzata Gawrońska
Mateusz Kowalik
Joanna Duch
Katarzyna Kazimierczuk dr hab.
Mariusz Makowski dr

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Keywords

RHODIUM(III) ION COMPLEXES SULFA DRUG

Details

Category:

Articles

Type:

artykuły w czasopismach

Published in:

POLYHEDRON no. 221,
ISSN: 0277-5387

Language:

English

Publication year:

2022

Bibliographic description:

Gawrońska M., Kowalik M., Duch J., Kazimierczuk K., Makowski M.: Sulfonamides with hydroxyphenyl moiety: Synthesis, structure, physicochemical properties, and ability to form complexes with Rh(III) ion// POLYHEDRON -Vol. 221, (2022), s.115865-

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