Synthesis and antiproliferative activity of conjugates of adenosine with muramyl dipeptide and nor-muramyl dipeptide derivatives

Monika Samsel; Krystyna Dzierzbicka; Piotr Trzonkowski

doi:10.1016/j.bmcl.2014.05.043

Synthesis and antiproliferative activity of conjugates of adenosine with muramyl dipeptide and nor-muramyl dipeptide derivatives

Abstract

We synthesized a series of MDP(D,D) and nor-MDP(D,D) derivatives conjugated with adenosine through a spacer as potential immunosuppressants. New conjugates were evaluated on two leukemia cell lines (Jurkat and L1210) and PBMC from healthy donors.

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Authors (3)

Monika Samsel mgr
Krystyna Dzierzbicka prof. dr hab. inż.
Piotr Trzonkowski
- GUMed Zakład Immunologii i Transplantologii

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Category:: Articles
Type:: artykuł w czasopiśmie wyróżnionym w JCR
Published in:: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS no. 24, edition 15, pages 3587 - 3591,
ISSN: 0960-894X
Language:: English
Publication year:: 2014
Bibliographic description:: Samsel M., Dzierzbicka K., Trzonkowski P.: Synthesis and antiproliferative activity of conjugates of adenosine with muramyl dipeptide and nor-muramyl dipeptide derivatives// BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. -Vol. 24, iss. 15 (2014), s.3587-3591
DOI:: Digital Object Identifier (open in new tab) 10.1016/j.bmcl.2014.05.043
Verified by:: Gdańsk University of Technology