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Synthesis and biological activity of novel ester derivatives of N3-(4-metoxyfumaroyl)-(S)-2,3-diaminopropanoic acid containing amide and keto function as inhibitors of glucosamine-6-phosphate synthase
Abstract
A short series of novel ester derivatives of N3-4-methoxyfumaroyl-(S)-2,3-diaminopropanoic acid (FMDP) containing amido or keto functions have been designed and synthesized. Their antifungal activity and inhibitory properties toward fungal glucosamine-6-phosphate synthase has also been evaluated. The obtained compounds 11-13 and 15-17 demonstrated good antifunga activity against Candida albicans. Compounds 11-13 displayed also potent inhibitory activity against fungal glucosamine-6-phosphate synthase comparable to that of FMDP.
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Authors (4)
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Schielmann Marta dr inż.
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
no. 26,
edition 15,
pages 3586 - 3589,
ISSN: 0960-894X - Language:
- English
- Publication year:
- 2016
- Bibliographic description:
- Pawlak D., Marta S., Wojciechowski M., Andruszkiewicz R.: Synthesis and biological activity of novel ester derivatives of N3-(4-metoxyfumaroyl)-(S)-2,3-diaminopropanoic acid containing amide and keto function as inhibitors of glucosamine-6-phosphate synthase// BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. -Vol. 26, iss. 15 (2016), s.3586-3589
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.bmcl.2016.06.016
- Verified by:
- Gdańsk University of Technology
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