Search
Synthesis and biological activity of novel ester derivatives of N3-(4-metoxyfumaroyl)-(S)-2,3-diaminopropanoic acid containing amide and keto function as inhibitors of glucosamine-6-phosphate synthase
Abstract
A short series of novel ester derivatives of N3-4-methoxyfumaroyl-(S)-2,3-diaminopropanoic acid (FMDP) containing amido or keto functions have been designed and synthesized. Their antifungal activity and inhibitory properties toward fungal glucosamine-6-phosphate synthase has also been evaluated. The obtained compounds 11-13 and 15-17 demonstrated good antifunga activity against Candida albicans. Compounds 11-13 displayed also potent inhibitory activity against fungal glucosamine-6-phosphate synthase comparable to that of FMDP.
Citations
-
1 3
CrossRef
-
0
Web of Science
-
1 5
Scopus
Authors (4)
-
Schielmann Marta dr inż.
Cite as
Full text
full text is not available in portal
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
no. 26,
edition 15,
pages 3586 - 3589,
ISSN: 0960-894X - Language:
- English
- Publication year:
- 2016
- Bibliographic description:
- Pawlak D., Marta S., Wojciechowski M., Andruszkiewicz R.: Synthesis and biological activity of novel ester derivatives of N3-(4-metoxyfumaroyl)-(S)-2,3-diaminopropanoic acid containing amide and keto function as inhibitors of glucosamine-6-phosphate synthase// BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. -Vol. 26, iss. 15 (2016), s.3586-3589
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.bmcl.2016.06.016
- Verified by:
- Gdańsk University of Technology
seen 139 times
Recommended for you
Emerging anticancer activity of candidal glucoseamine-6-phosphate synthase inhibitors upon nanoparticle-mediated delivery
- A. Kertmen,
- J. Przysiecka,
- E. Coy
- + 4 authors
2019