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Synthesis and biological evaluation of thiophosphate tricyclic coumarin derivatives as steroid sulfatase inhibitors
Abstract
Steroid sulfatase (STS) enzyme inhibition is an important approach to the management of hormone-dependent breast cancer. In this paper, we report convenient methods for the synthesis and biological evaluation of thiophosphate tricyclic coumarin analogs exhibiting STS activity. The described methods are based on the straightforward preparation of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-2-one, 3-hydroxy- 7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one, and 3-hydroxy-8,9,10,11-tetrahydro- 7H-cyclohepta[c]chromen-6-one and their further modification by the introduction of various thiophosphate moieties. The inhibition properties of the synthesized compounds were tested toward STS isolated from human placenta. Most of the new STS inhibitors possessed good to moderate activity toward STS. During the course of our investigation, the largest inhibitory effects in the STS enzyme assays were observed for the two compounds 3f and 4r, with IC50 values of 13.3 and 30.3mM, respectively (the IC50 value of 1mM for the 665-COUMATE was used as a reference). The structure–activity relationships of the synthesized coumarin derivatives toward STS enzymes are discussed.
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Authors (6)
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Maciej Masłyk
- The John Paul II Catholic University of Lublin Department of Molecular Biology, Faculty of Biotechnology and Environment Sciences
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Bartłomiej Gielniewski
- The John Paul II Catholic University of Lublin Department of Molecular Biology, Faculty of Biotechnology and Environment Sciences
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- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
no. 17,
edition 11,
pages 1091 - 1096,
ISSN: 1028-6020 - Language:
- English
- Publication year:
- 2015
- Bibliographic description:
- Kozak W., Daśko M., Masłyk M., Gielniewski B., Rachoń J., Demkowicz S.: Synthesis and biological evaluation of thiophosphate tricyclic coumarin derivatives as steroid sulfatase inhibitors// JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH. -Vol. 17, iss. 11 (2015), s.1091-1096
- DOI:
- Digital Object Identifier (open in new tab) 10.1080/10286020.2015.1054815
- Verified by:
- Gdańsk University of Technology
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