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Abstract
1,3,4,9-tetrahydropyrano[3,4-b ]indole-1-acetic acid derivatives are of interest for pharmaceutical research as a core structure for synthesis of biological active substance - Etodolac (selective Cyclooxygenase-2 inhibitor, which belongs to the Non-steroidal Anti-inflammatory Drug, NSAID, that shows a clin-ically effective analgesic and anti-inflammatory activity). Here the way of synthesis of two 1,3,4,9-tetrahydropyrano[3,4-b ]indole-1-acetic acid derivatives, impurities of Etodolac generated dur-ing drug production process, is presented. The title compounds were prepared in eight steps procedure which differs from previ-ously reported with respect to the way of constructing 1,3,4,9-tetrahydropyranring in molecule. Moreover, reaction conditions have been optimised and more efficient purification methods were introduced.
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Details
- Category:
- Monographic publication
- Type:
- rozdział, artykuł w książce - dziele zbiorowym /podręczniku w języku o zasięgu międzynarodowym
- Title of issue:
- PhD Interdisciplinary Journal. No. 1 strony 75 - 78
- Language:
- English
- Publication year:
- 2013
- Bibliographic description:
- Skwarecki A.: Synthesis of disubstituted 1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids derivatives// PhD Interdisciplinary Journal. No. 1/ ed. M. Czubenko Gdańsk: Gdańsk University of Technology, 2013, s.75-78
- Verified by:
- Gdańsk University of Technology
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