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Abstract
Polysaccharides (PSAs) are carbohydrate-based macromolecules widely used in the biomedical field, either in their pure form or in blends/nanocomposites with other materials. The relationship between structure, properties, and functions has inspired scientists to design multifunctional PSAs for various biomedical applications by incorporating unique molecular structures and targeted bulk properties. Multiple strategies, such as conjugation, grafting, cross-linking, and functionalization, have been explored to control their mechanical properties, electrical conductivity, hydrophilicity, degradability, rheological features, and stimuli-responsiveness. For instance, custom-made PSAs are known for their worldwide biomedical applications in tissue engineering, drug/gene delivery, and regenerative medicine. Furthermore, the remarkable advancements in supramolecular engineering and chemistry have paved the way for mission-oriented biomaterial synthesis and the fabrication of customized biomaterials. These materials can synergistically combine the benefits of biology and chemistry to tackle important biomedical questions. Herein, we categorize and summarize PSAs based on their synthesis methods, and explore the main strategies used to customize their chemical structures. We then highlight various properties of PSAs using practical examples. Lastly, we thoroughly describe the biomedical applications of tailor-made PSAs, along with their current existing challenges and potential future directions.
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4
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0
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2
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Authors (8)
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Farzad Seidi
-
Aleksander Hejna dr inż.
-
Payam Zarrintaj
-
Navid Rabiee
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Mohammad Saeb
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Sidi A. Bencherif
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
ACS Applied Bio Materials
no. 7,
pages 4193 - 4230,
ISSN: - Language:
- English
- Publication year:
- 2024
- Bibliographic description:
- Khodadadiyazdi M., Seidi F., Hejna A., Zarrintaj P., Rabiee N., Kucińska-Lipka J., Saeb M., Bencherif S. A.: Tailor-Made Polysaccharides for Biomedical Applications// ACS Applied Bio Materials -,iss. 7 (2024), s.4193-4230
- DOI:
- Digital Object Identifier (open in new tab) 10.1021/acsabm.3c01199
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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