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Abstract
Herein, the stereostructure of the aromatic heptaene macrolide (AHM) antifungal antibiotic candicidin A3 (syn. ascosin A3, levorin A3) has been established upon the 2D NMR studies, consisting of DQF-COSY, TOCSY, ROESY, HSQC and HMBC experiments, as well as upon extensive molecular dynamics simulations. The geometry of the heptaenic chromophore was defined as: (22E, 24E, 26Z, 28Z, 30E, 32E, 34E). The previously unreported absolute configuration of the chiral centres of candicidin A3 was established as: (3R,9 R, 11 S, 13 S, 15 R, 17 S, 18 R, 19 S, 21 R, 36 S, 37 R, 38 S, 40 S, 41 S).
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- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
NATURAL PRODUCT RESEARCH
no. 34,
pages 2869 - 2879,
ISSN: 1478-6419 - Language:
- English
- Publication year:
- 2019
- Bibliographic description:
- Borzyszkowska-Bukowska J., Szczeblewski P., KONKOL A., GRYNDA J., Szwarc-Karabyka K., Laskowski T.: The complete stereochemistry of the antibiotic candicidin A3 (syn. ascosin A3, levorin A3)// NATURAL PRODUCT RESEARCH. -Vol. 34, iss. 20 (2019), s.2869-2879
- DOI:
- Digital Object Identifier (open in new tab) 10.1080/14786419.2019.1596095
- Sources of funding:
- Verified by:
- Gdańsk University of Technology
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