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The effect of sunscreen 4‐methylbenzylidene camphor in different and reproductive models, its bioaccumulation and molecular effects on ligand‐receptor interaction, and protein expression
Abstract
4-Methylbenzylidene camphor (4-MBC) is a photo-absorbing UV filter prevalently used in cosmetics, which can be absorbed into circulation and cause systemic effects. 4-MBC is continued to be released in the environment despite the growing knowledge about its bioaccumulation and endocrine disrupting effects. Previous reviews have mentioned UV-filter together but this review considers 4-MBC alone, due to its prevalence and concerning health effects. This review considers 4-MBC’s potential effects on human health regarding systemic and molecular effects, with the main focus on reproduction. Also, the potential bioaccumulation and interactions with receptor systems such as the oestrogen receptors β and α, and progesterone receptor are covered. Additionally, previous studies about 4-MBC’s effects on mRNA and protein expression, especially in the prostate and the brain are analysed. Furthermore, 4-MBC is reported to act with inflammatory pathways by activating p38 MAPK and NF-κB, leading to the production of inflammatory TNF-α and IL-6. 4-MBC was also found to induce apoptosis and inhibit cell proliferation and DNA repair. In conclusion, 4-MBC has wide-ranging effects in many different models interacting with multiple pathways causing long-term effects even at low doses and this knowledge can guide governmental risk assessment, regulation divisions and chemical industries.
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Authors (8)
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Cassandra Lax
- Department of Surgical Sciences, Functional pharmacology and neuroscience, Uppsala University, Uppsala, Sweden
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Elin Wicksell
- Department of Surgical Sciences, Functional pharmacology and neuroscience, Uppsala University, Uppsala, Sweden
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Anastasia Grip
- Department of Surgical Sciences, Functional pharmacology and neuroscience, Uppsala University, Uppsala, Sweden
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Jenni Viivi Linnea Niemi
- Department of Surgical Sciences, Functional pharmacology and neuroscience, Uppsala University, Uppsala, Sweden
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Wen Liu
- Department of Surgical Sciences, Functional pharmacology and neuroscience, Uppsala University, Uppsala, Sweden
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Alexandra Rafeletou
- Department of Surgical Sciences, Functional pharmacology and neuroscience, Uppsala University, Uppsala, Sweden
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Helgi B. Schiöth
- Department of Surgical Sciences, Functional pharmacology and neuroscience, Uppsala University, Uppsala, Sweden
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1111/bcpt.13901
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
no. 133,
pages 130 - 141,
ISSN: 1742-7835 - Language:
- English
- Publication year:
- 2023
- Bibliographic description:
- Lax C., Wicksell E., Grip A., Niemi J. V. L., Liu W., Rafeletou A., Kudłak B., Schiöth H. B.: The effect of sunscreen 4‐methylbenzylidene camphor in different and reproductive models, its bioaccumulation and molecular effects on ligand‐receptor interaction, and protein expression// BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY -Vol. 133,iss. 2 (2023), s.130-141
- DOI:
- Digital Object Identifier (open in new tab) 10.1111/bcpt.13901
- Sources of funding:
-
- Statutory activity/subsidy
- Verified by:
- Gdańsk University of Technology
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