The influence of amorphous macrodiol, diisocyanate type and l-ascorbic acid modifier on chemical structure, morphology and degradation behavior of polyurethanes for tissue scaffolds fabrication - Publication - Bridge of Knowledge

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The influence of amorphous macrodiol, diisocyanate type and l-ascorbic acid modifier on chemical structure, morphology and degradation behavior of polyurethanes for tissue scaffolds fabrication

Abstract

Studies described in this work were related to the bulk synthesis and characterization of polyurethanes (PURs) obtained with the use of cyclic 4,4′-methylene bis(cyclohexyl isocyanate) (HMDI) or linear 1,6-hexamethylene diisocyanate (HDI), amorphous α,ω-dihydroxy(ethylene-butylene adipate) macrodiol (PEBA), 1,4-butandiol (BDO) chain extender and dibutyltin dilaurate (DBTDL) catalyst. Obtained PURs were modified with l-ascorbic acid (AA). Raw materials and modifier improving biocompatybility were carefully selected due to the planned use of obtained PURs as a tissue scaffold fabrication material. Performed chemical structure studies (FTIR, ATR-IR, 2D NMR), morphology observations (SEM, TEM and AFM) and characterization of degradation profile revealed that PURs obtained by using HDI were representing a significantly better characteristic than those obtained by using HMDI. Thus, the HDI-based PURs were suggested for further development as a materials useful for tissue scaffolds fabrication in the field of tissue engineering.

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Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
POLYMER DEGRADATION AND STABILITY no. 163, pages 52 - 67,
ISSN: 0141-3910
Language:
English
Publication year:
2019
Bibliographic description:
Gubańska I., Kucińska-Lipka J., Janik H.: The influence of amorphous macrodiol, diisocyanate type and l-ascorbic acid modifier on chemical structure, morphology and degradation behavior of polyurethanes for tissue scaffolds fabrication// POLYMER DEGRADATION AND STABILITY. -Vol. 163, (2019), s.52-67
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.polymdegradstab.2019.02.025
Verified by:
Gdańsk University of Technology

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